Molecular Formula: C₁₀H₁₁N₂⁺
Molecular Weight: 159.21 g/mol
Chemical Name: 5-amino-1-methylquinolinium
Purity: >99%
Capsule Size: 50mg per capsule
Bottle Size: 60 capsules
Storage: Room temperature, protect from moisture
Product Overview
5-Amino-1MQ represents revolutionary NNMT inhibitor technology designed for comprehensive metabolic enhancement, weight management, and longevity research applications. This small molecule compound demonstrates exceptional ability to block nicotinamide N-methyltransferase enzyme activity, preventing NAD+ depletion while activating sirtuin pathways associated with healthy aging and metabolic optimization. Unlike traditional weight-loss compounds that rely on appetite suppression or stimulant effects, 5-Amino-1MQ works at the cellular level to enhance energy efficiency, promote fat oxidation, and support muscle preservation through direct enzymatic modulation.
Revolutionary NNMT Inhibition Mechanism
5-Amino-1MQ functions as a potent selective inhibitor of nicotinamide N-methyltransferase with IC₅₀ = 1μM, preventing the enzyme from converting nicotinamide to 1-methylnicotinamide. This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety.
Primary Research Applications
Weight Management & Fat Loss Studies
Clinical validation demonstrates remarkable 7% body weight reduction over 10 days in diet-induced obese mice without changes in food intake compared to controls. Research shows 30% reduction in fat mass, decreased adipocyte size, and normalized plasma cholesterol levels equal to non-obese animals. Studies reveal enhanced fatty acid oxidation, increased energy expenditure, and improved metabolic efficiency through direct NNMT inhibition, positioning it as breakthrough tool for investigating obesity mechanisms without appetite suppression.
Metabolic Syndrome & Diabetes Research
Studies demonstrate improved glucose tolerance, enhanced insulin sensitivity, and reduced fasting glucose/insulin levels across multiple obesity models. Research shows increased GLUT4 expression leading to better glucose clearance, enhanced insulin receptor sensitivity, and normalized metabolic parameters. Applications include investigating type 2 diabetes prevention, insulin resistance mechanisms, and novel therapeutic approaches for metabolic dysfunction through enzymatic pathway modulation.
Anti-Aging & Longevity Studies
Research reveals activation of sirtuin 1 pathways through preserved NAD+ levels, triggering longevity-associated genetic programs including enhanced DNA repair, improved mitochondrial function, and reduced inflammatory responses. Studies demonstrate protection against diabetes, obesity, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer through comprehensive metabolic optimization. Applications encompass investigating aging mechanisms, healthspan extension, and cellular resilience enhancement.
Muscle Function & Regeneration Research
Studies show enhanced muscle stem cell activation in aged models with 2-fold larger myofiber cross-sections and 70% greater contractile force compared to controls. Research demonstrates improved muscle repair following injury, enhanced recovery from exercise, and protection against muscle wasting conditions including Duchenne muscular dystrophy. Applications include investigating sarcopenia prevention, athletic performance enhancement, and age-related muscle decline through stem cell pathway activation.
Cognitive Enhancement Studies
Research suggests potential cognitive benefits through NAD+ preservation in brain tissue, as NAD+ depletion impairs synaptic transmission and neuromuscular junction communication. Studies indicate possible nootropic effects through enhanced cellular energy metabolism, improved mitochondrial function, and reduced oxidative stress. Applications encompass investigating cognitive aging, neurodegenerative disease prevention, and brain performance optimization through metabolic enhancement.
Mechanism of Action
NNMT Enzyme Inhibition: Selective blockade preventing nicotinamide methylation and NAD+ consumption
NAD+ Preservation: Enhanced cellular energy cofactor availability supporting mitochondrial function
Sirtuin 1 Activation: Longevity gene stimulation promoting DNA repair and metabolic optimization
GLUT4 Upregulation: Improved glucose transporter expression enhancing insulin sensitivity
Metabolic Efficiency: Increased energy expenditure with preferential fat oxidation over storage
Stem Cell Activation: Enhanced muscle repair capacity and regenerative potential
Research Advantages
Oral Bioavailability: High membrane permeability enabling convenient capsule administration
Selective Inhibition: Specific NNMT targeting without affecting related enzymatic pathways
No Appetite Effects: Weight loss through metabolic enhancement rather than caloric restriction
Multi-System Benefits: Simultaneous obesity, diabetes, aging, and performance applications
Rapid Onset: Measurable metabolic improvements within days of administration
Safety Profile: No observable adverse effects in extensive preclinical studies
Exercise Synergy: Additive benefits when combined with physical training protocols
Quality Specifications
Every 5-Amino-1MQ capsule batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Molecular weight confirmation at 159.21 g/mol
CAS number validation (42464-96-0)
PubChem CID verification (950107)
NNMT inhibition potency assessment (IC₅₀ = 1μM)
Membrane permeability validation
Certificate of Analysis provided with shipment
Storage & Administration
Store capsules at room temperature in sealed bottle. Protect from moisture and excessive heat. Capsules maintain stability for 24 months when stored properly. Each capsule contains precisely measured 50mg dose enabling consistent research protocols. High oral bioavailability and membrane permeability ensure effective systemic distribution without complex preparation requirements.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.