Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: 390.349 g/mol
Sequence: Ala-Glu-Asp-Gly (AEDG)
Purity: >99%
Capsule Size: 3mg per capsule
Bottle Size: 60 capsules
Storage: Room temperature, protect from moisture
Product Overview
Epitalon represents revolutionary telomerase-activating peptide technology designed for comprehensive anti-aging, longevity, and cellular regeneration research applications. This synthetic tetrapeptide, originally developed by Professor Vladimir Khavinson, demonstrates exceptional ability to activate telomerase enzyme, extend telomere length, and modulate gene expression associated with aging processes. Unlike traditional anti-aging interventions, Epitalon works directly at the chromosomal level to preserve cellular integrity while promoting natural regenerative mechanisms through pineal gland regulation and epigenetic modification.
Revolutionary Telomerase Mechanism
Epitalon functions through unprecedented activation of telomerase, the enzyme responsible for maintaining protective telomere caps on DNA chromosomes. The peptide directly induces expression of the catalytic subunit hTERT, triggering enzymatic activity that extends telomere length beyond the Hayflick limit. This mechanism enables cells to continue dividing past their normal lifespan, with research demonstrating extension from 34th passage termination to beyond 44th passage in human fibroblast cultures while restoring telomere lengths to levels comparable to young cells.
Primary Research Applications
Anti-Aging & Longevity Studies
Comprehensive clinical validation demonstrates remarkable life extension effects with up to 27% lifespan increase in animal models. Human studies show significant telomere length increases in blood cells of patients aged 60-80, with 4-fold mortality reduction when combined with thymalin. Research reveals enhanced physical endurance, improved circadian rhythm optimization, and restored hormonal balance, positioning Epitalon as breakthrough tool for investigating cellular aging mechanisms and longevity interventions.
Gene Expression & Epigenetic Research
Studies demonstrate Epitalon's ability to modulate expression of multiple aging-related genes including CD5 for immune system enhancement, IL-2 for white blood cell production, MMP2 for collagen maintenance, and PER1 for circadian rhythm regulation. Research shows 30-45% increased fibroblast activity and enhanced protein synthesis through Tram1 regulation, making it invaluable for investigating epigenetic aging mechanisms and cellular reprogramming strategies.
Neurological Enhancement Studies
Research reveals significant neuroprotective effects including enhanced production of neuronal differentiation markers nestin, GAP43, β-tubulin III, and doublecortin. Studies demonstrate improved retinal bioelectric function, restored melatonin secretion following brain injury, and enhanced cognitive performance. Clinical trials in retinitis pigmentosa showed 90% patient improvement with increased visual acuity and expanded visual field borders.
Cancer Prevention Research
Clinical validation demonstrates significant tumor suppression with reduced spontaneous tumor incidence and decreased metastasis rates in multiple cancer models. Research shows slowed growth of HER-2/neu positive breast cancers through PER1 activation, which is typically under-expressed in malignancies. Studies reveal enhanced immune surveillance capabilities and reduced cancer-promoting inflammatory pathways through telomerase regulation.
Sleep & Circadian Rhythm Research
Studies demonstrate restoration of normal melatonin production through pineal gland regulation, improved sleep quality, and normalized circadian rhythm patterns. Research shows protection against jet lag, shift work disorders, and sleep disruptions while enhancing overall hormonal balance. Applications include investigating sleep-aging connections and therapeutic approaches for circadian rhythm disorders.
Mechanism of Action
Telomerase Activation: Direct induction of hTERT expression and enzymatic activity extending cellular lifespan
Gene Expression Modulation: Epigenetic regulation of aging-related genes promoting youthful cellular function
Pineal Gland Restoration: Enhanced melatonin production and circadian rhythm optimization
Antioxidant Enhancement: Increased superoxide dismutase, glutathione peroxidase, and anti-inflammatory responses
Chromatin Remodeling: Decondensation of heterochromatin in aged cells reactivating silenced genes
Cellular Protection: Reduced apoptosis, enhanced DNA repair, and improved stress resistance
Research Advantages
Oral Bioavailability: Convenient micro-encapsulated capsule form with demonstrated systemic absorption
Multi-System Effects: Simultaneous anti-aging, neuroprotective, sleep, and immune enhancement applications
Clinical Foundation: 50 years of research validation with extensive human studies confirming safety and efficacy
Natural Origin: Synthetic version of endogenous pineal gland peptide with established physiological roles
Gene Reset Capability: Unique ability to restore pathological aging gene expression patterns to health
Life Extension Proof: Demonstrated lifespan extension in multiple species with mortality reduction in humans
Safety Profile: No significant adverse effects reported in decades of clinical applications
Quality Specifications
Every Epitalon capsule batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Tetrapeptide sequence verification (Ala-Glu-Asp-Gly)
Molecular weight confirmation at 390.349 g/mol
CAS number validation (307297-39-8)
PubChem CID verification (219042)
Telomerase activation bioactivity assessment
Certificate of Analysis provided with shipment
Storage & Administration
Store capsules at room temperature in sealed bottle. Protect from moisture and excessive heat. Capsules maintain stability for 24 months when stored properly. Each capsule contains precisely measured 3mg dose enabling consistent research protocols. Micro-encapsulation technology ensures optimal bioavailability and protection from digestive enzymes.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.