FOXO4-DRI 10mg (Proxofim) 
Advanced Senolytic Research Compound for Cellular Aging Studies
Product Overview
FOXO4-DRI (D-Retro-Inverso), also known as Proxofim, is a cutting-edge synthetic peptide designed for advanced aging research and cellular senescence studies. This innovative compound represents a breakthrough in senolytic research, offering researchers a powerful tool to investigate cellular aging mechanisms and potential therapeutic applications.
Key Features & Benefits
✓ Selective Senolytic Activity: FOXO4-DRI demonstrates remarkable selectivity in targeting senescent cells while preserving healthy cell populations
✓ Enhanced Stability: The D-retro-inverso modification provides superior resistance to proteolytic degradation, extending half-life and bioavailability
✓ Cell-Penetrating Design: Engineered with HIV-TAT sequence for efficient cellular uptake and sustained intracellular presence
✓ Research Validated: Extensively studied in peer-reviewed research with applications in aging, fibrosis, and regenerative medicine
Mechanism of Action
FOXO4-DRI functions through a sophisticated molecular mechanism:
Disrupts FOXO4-p53 Interaction: Competitively binds to p53, preventing normal FOXO4 sequestration
Induces Nuclear p53 Exclusion: Releases p53 from nuclear sequestration, allowing translocation to mitochondria
Triggers Selective Apoptosis: Activates caspase-3/7 pathways specifically in senescent cells
Preserves Healthy Cells: Shows minimal impact on non-senescent cell populations
 
Research Applications
 
Aging & Longevity Studies: Investigate cellular senescence mechanisms and potential life extension strategies
Tissue Regeneration: Study applications in cartilage repair, wound healing, and organ function restoration
Fibrosis Research: Explore therapeutic potential in pulmonary fibrosis and other fibrotic conditions
Reproductive Health: Investigate age-related reproductive decline and testosterone insufficiency
Cardiovascular Research: Study heart disease prevention through proteasome activity enhancement
Neurodegeneration Studies: Explore potential applications in Alzheimer's, Parkinson's, and other neurodegenerative diseases
Technical Specifications
Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄
Molecular Weight: 5,358.05 Da
Purity: >98% (HPLC verified)
Appearance: White lyophilized powder
Storage: Store at -20°C, protect from light
Solubility: Soluble in sterile water or saline
Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH
Research Highlights
Recent studies have demonstrated FOXO4-DRI's potential across multiple research areas:
Improved Organ Function: Animal studies show enhanced fitness, fur density, and renal function in aged mice
Tissue Homeostasis: Restoration of tissue balance through selective elimination of dysfunctional cells
Reduced Inflammation: Decreased senescence-associated secretory phenotype (SASP) markers
Enhanced Regeneration: Improved cellular regeneration capacity in various tissue types
 
Quality Assurance
 
Each batch undergoes rigorous quality control testing:
High-Performance Liquid Chromatography (HPLC) purity verification
Mass spectrometry molecular weight confirmation
Sterility and endotoxin testing
Certificate of Analysis provided with each order
Usage Guidelines
For Research Use Only: FOXO4-DRI is intended exclusively for in-vitro research and scientific studies. Not approved for human consumption or therapeutic use.
Recommended Protocols: Consult current literature for optimal concentration ranges and experimental conditions. Initial studies suggest effective concentrations in the micromolar range for cell culture applications.
Safety Considerations: Handle with appropriate laboratory safety equipment. Store properly to maintain stability and potency.
Why Choose PeptidesAlpha?
Premium Quality: Pharmaceutical-grade synthesis with >98% purity
Fast Shipping: Rapid, secure delivery with proper cold-chain handling
Expert Support: Technical assistance from our peptide specialists
Competitive Pricing: Best value for research-grade peptides
Reliable Supply: Consistent availability for ongoing research projects
Order Information
Product Code: PA-FOXO4-DRI-10MG
Package Size: 10mg lyophilized powder
Storage Requirements: -20°C freezer storage recommended
Shelf Life: 24 months when stored properly
Transform your aging research with FOXO4-DRI from PeptidesAlpha - where cutting-edge science meets uncompromising quality.