Molecular Formula: C₁₆H₂₈CuN₆O₆²⁻
Molecular Weight: 463.98 g/mol
Sequence: Gly-His-Lys-Cu²⁺
Purity: >99%
Capsule Size: 2mg per capsule
Bottle Size: 60 capsules
Storage: Room temperature, protect from moisture
Product Overview
GHK-Cu represents revolutionary copper-chelating peptide technology designed for comprehensive anti-aging, wound healing, and regenerative medicine research applications. This naturally occurring tripeptide forms an ionic complex with copper in human plasma, demonstrating exceptional ability to modulate gene expression on a massive scale while providing potent anti-inflammatory, antioxidant, and tissue repair capabilities. Originally isolated in 1973, GHK-Cu has become one of the most extensively studied peptides in regenerative medicine, with natural plasma levels declining from 200 ng/ml at age 20 to 80 ng/ml by age 60.
Revolutionary Gene Expression Mechanism
GHK-Cu functions through unprecedented modulation of human gene expression, affecting 31.2% of all human genes with changes greater than 50%. The peptide increases expression in 59% of affected genes while suppressing 41%, essentially resetting pathological gene patterns back to healthier states. This epigenetic regulation involves copper-dependent activation of cellular pathways including enhanced DNA repair, increased antioxidant enzyme production, and stimulation of regenerative processes while simultaneously suppressing inflammatory and destructive gene programs.
Primary Research Applications
Anti-Aging & Longevity Studies
Comprehensive research demonstrates GHK-Cu's ability to reverse multiple aging hallmarks through direct gene expression modification. Studies show restoration of youthful gene patterns, enhanced DNA repair mechanisms, and activation of 47 DNA repair genes while suppressing only 5. Clinical trials reveal significant improvements in skin elasticity, wrinkle reduction up to 35%, and enhanced cellular regeneration, positioning it as breakthrough tool for investigating aging mechanisms and longevity interventions.
Wound Healing & Tissue Repair Research
Extensive validation demonstrates accelerated wound closure rates exceeding 60% compared to controls, enhanced collagen synthesis, and improved angiogenesis. Research shows GHK-Cu increases collagen production 9-fold in healthy tissue while stimulating elastin synthesis and reducing metalloproteinase activity. Applications include investigating diabetic wound healing, surgical recovery enhancement, and chronic wound management through comprehensive tissue remodeling mechanisms.
Neurological Enhancement Studies
Research reveals significant neuroprotective effects including enhanced nerve outgrowth, increased production of neurotrophins NGF, NT-3, and NT-4, and improved cognitive function in aging models. Studies demonstrate protection against brain edema, reduced inflammatory cytokines TNF-α and IL-1β, and enhanced neuronal survival following injury. Applications encompass stroke recovery research, neurodegenerative disease prevention, and cognitive aging investigations.
Cancer Prevention Research
Clinical validation shows suppression of 70% of genes overexpressed in aggressive metastatic colon cancer, reduced tumor incidence, and enhanced immune surveillance capabilities. Research demonstrates GHK-Cu's ability to prevent toxic amyloid-beta formation associated with Alzheimer's disease while reducing cancer-promoting inflammatory pathways. Applications include investigating cancer metastasis prevention, tumor suppression mechanisms, and oncogene regulation strategies.
Cardiovascular Protection Studies
Studies reveal enhanced angiogenesis, improved endothelial function, and reduced cardiovascular inflammatory markers. Research shows GHK-Cu promotes blood vessel formation, enhances cardiac tissue repair, and provides protection against ischemia-reperfusion injury through enhanced antioxidant responses and reduced oxidative damage.
Mechanism of Action
Gene Expression Modulation: Comprehensive regulation of 31.2% of human genes promoting health and longevity
Copper Chelation: Essential cofactor delivery for enzymatic processes including collagen cross-linking
Collagen Enhancement: Stimulation of Types I, III, and VII collagen synthesis with improved tissue architecture
Anti-Inflammatory Action: Suppression of TNF-α, IL-6, and other pro-inflammatory cytokines
Antioxidant Protection: Enhanced superoxide dismutase activity and free radical scavenging
DNA Repair Activation: Upregulation of 47 genes involved in cellular repair and protection mechanisms
Research Advantages
Oral Bioavailability: Convenient capsule administration with demonstrated systemic distribution
Safety Profile: Extensive 50-year clinical history with no significant adverse effects
Multi-System Effects: Simultaneous anti-aging, wound healing, neuroprotective, and anti-cancer applications
Gene Reset Capability: Unique ability to restore pathological gene expression patterns to health
Natural Origin: Endogenous peptide with established physiological roles and safety profile
Dose-Dependent Response: Effective at nanomolar concentrations enabling precise research protocols
Clinical Foundation: Extensive validation across multiple therapeutic areas with proven mechanisms
Quality Specifications
Every GHK-Cu capsule batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Tripeptide sequence verification (Gly-His-Lys)
Copper complex formation confirmation
Molecular weight validation at 463.98 g/mol
CAS number verification (49557-75-7)
PubChem CID confirmation (156588903)
Certificate of Analysis provided with shipment
Storage & Administration
Store capsules at room temperature in sealed bottle. Protect from moisture and excessive heat. Capsules maintain stability for 24 months when stored properly. Each capsule contains precisely measured 2mg dose enabling consistent research protocols. For research applications, systemic distribution occurs regardless of administration route, making oral dosing highly effective.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.