Growth Hormone Releasing Hormone (GHRH) is a naturally occurring peptide produced by arcuate neurons in the hypothalamus. Its main role is to signal the pituitary gland to release growth hormone (GH), an essential mediator of growth, body composition, metabolism, and overall physiological health. Through binding to its specific receptor, GHRH initiates the pulsatile secretion of GH, a rhythm vital for proper development, tissue repair, muscle growth, and fat reduction.
What is GHRH?
GHRH stands for Growth Hormone Releasing Hormone and exists as a peptide of 37–44 amino acids (most commonly 44) with a sequence that stimulates the pituitary’s GH release. It not only regulates linear growth and lean body mass, but also modulates inflammation, pain sensitivity, and even sleep cycles. Uniquely, GHRH is released in pulses, and this pattern is essential for maximizing the efficiency of growth hormone action and reducing side effects.
GHRH Biological Importance
Regulates Growth & Body Composition: GHRH stimulates muscle development, increases lean mass, and decreases fat stores by boosting the pituitary’s output of growth hormone.
Supports Healthy Sleep Cycles: GHRH is integral to the initiation and regulation of non-REM sleep, and research indicates exogenous GHRH can enhance restorative sleep.
Metabolic & Cognitive Roles: Research in obesity, trauma, and aging shows that GHRH is pivotal in maintaining a healthy metabolism, supporting cognitive function, and preventing excess fat accumulation.
Anti-inflammatory & Analgesic Effects: Evidence from animal models demonstrates that GHRH modulates inflammatory pathways and can reduce pain sensitivity—distinct from opioid and NSAID mechanisms.
Unique Structure
Sequence: DL-Tyr-DL-Ala-DL-Asp-DL-Ala-DL-xiIle-DL-Phe-...Leu-DL-Qln-DL-Gln-Gly-DL-Glu-DL-Ser-DL-Asn-DL-Gln-DL-Glu-DL-Arg-Gly-DL-Ala-DL-Arg-DL-Ala-DL-Arg-DL-Leu
Molecular Formula: C215H358N72O66S
Molecular Weight: 5039.7 g/mol
Synonyms: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin
CAS Number: 9034-39-3
GHRH in Research
Sleep and Neurological Health: GHRH has been shown to promote non-REM sleep and regulate sleep cycles. Its balance with other hormones, like corticotropin-releasing hormone (CRH), may help explain the links between sleep disorders and mood disturbances.
Obesity and Muscle Metabolism: GHRH levels impact body composition, and supplementation in research shows potential for breaking cycles of obesity and muscle loss—key interests in age-related decline studies.
Pain & Anti-Inflammation: Animal studies demonstrate GHRH reduces inflammatory hyperalgesia and may have clinical implications for chronic pain and fibromyalgia research.
Prostate and Endocrine Support: GHRH and its analogues show promise for supporting normal prostate size and function in animal models, indicating possible future pathways for therapeutic research.
Variants and Analogues
Several analogues have been designed to increase GHRH’s stability, duration, or specificity. Notable examples include CJC-1295, Sermorelin, and Tesamorelin (FDA-approved for HIV-associated lipodystrophy), offering researchers a spectrum of options for targeting the growth hormone axis.
Product Specifications
Content: 5mg GHRH peptide per vial
Purity: >98% as verified by HPLC
Form: Lyophilized powder, laboratory research grade
Storage: Store in a cool, dry place as per laboratory protocol
Compliance Disclaimer
GHRH 5mg from PeptidesAlpha is offered strictly for in-vitro laboratory research use. Introduction into the human or animal body is forbidden by law. This peptide is neither a drug nor approved for any therapeutic, supplement, or diagnostic purpose.
Choose PeptidesAlpha for trusted, high-quality GHRH peptides to advance your research with confidence and scientific excellence.