GHRP-2 (Growth Hormone Releasing Peptide-2), also known as pralmorelin, is a synthetic growth hormone secretagogue designed to bind to the ghrelin/growth hormone secretagogue receptor. As the first of its kind, it plays a pioneering role in stimulating the natural secretion of growth hormone (GH) and has become a research standard for assessing growth hormone deficiency and secondary adrenal failure.
What is GHRP-2?
GHRP-2 is a short-chain peptide with the sequence D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys, and a molecular formula of C45H55N9O6 and molecular weight of 817.97 g/mol. Its biological activity exceeds that of earlier GHRPs, and it has been investigated for effects on muscle growth, appetite, immune system modulation, cardiac protection, and sleep regulation.
Key Research Areas
Muscle Structure Enhancement: Studies indicate GHRP-2 promotes muscle growth by boosting protein deposition while reducing protein breakdown, overcoming growth plateaus in challenging environments such as disease, stress, and undernutrition.
Appetite Stimulation: GHRP-2 reliably increases appetite, making it an area of active interest for supporting nutrition in chronic illness and age-related appetite loss.
Cardiac and Tissue Protection: Research suggests GHRP-2 may protect heart cells from programmed cell death (apoptosis), particularly valuable after ischemic events such as heart attacks. Analogue research further supports specialized receptor activity for cardiac protection.
Immune System Support: By rejuvenating the thymus and boosting T-cell production, GHRP-2 helps to promote adaptive immunity — an effect that addresses age-related decline in immune function.
Sleep Quality Improvement: Clinical observations show GHRP-2 increases beneficial stages of sleep (stages 3 and 4) by around 50% and REM by 20%. These changes correlate with better cognitive function, faster healing, and improved energy in research contexts.
Pain Modulation: GHRP-2 has action at selective opioid receptors, suggesting a direct role in pain relief apart from its impact on growth hormone secretion or injury healing.
Mechanism of Action
GHRP-2 binds specifically to the ghrelin receptor, stimulating the release of endogenous growth hormone from the pituitary gland. This mimics one of the body's natural mechanisms for GH secretion and provides a model for studying metabolic modulation, lean body mass accrual, and other health-related endpoints in both animal and in vitro models.
Product Specifications
Content: 5mg GHRP-2 peptide per vial
Sequence: D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys
Molecular Formula: C45H55N9O6
Molecular Weight: 817.97 g/mol
Synonyms: Pralmorelin, KP-102, GPA-748, WAY-GPA-748
CAS Number: 158861-67-7
Purity: High-purity research grade, HPLC-verified
Form: Lyophilized powder, to be handled following standard research protocols
Safety and Usage
GHRP-2 exhibits minimal to moderate side effects in research models, shows excellent subcutaneous and low oral bioavailability in mice, and is limited to investigational use only. Research dosages in animal models do not scale directly to human use and all findings are intended for laboratory analysis, not therapeutic application.
Compliance Disclaimer
All products, including GHRP-2 5mg from PeptidesAlpha, are strictly supplied for academic or laboratory research. They must not be introduced into humans or animals, nor used for any medical or diagnostic purposes. Not FDA approved for treatment, cure, or prevention of disease.
Rely on PeptidesAlpha for premier-quality peptides to support your breakthrough life science research and innovation.