Hexarelin is a synthetic peptide analogue of ghrelin and growth hormone secretagogues (GHS) known for its potent cardioprotective and muscle-preserving effects. It has been extensively studied for its ability to protect the heart following ischemic injury such as heart attack, improve lipid metabolism, and counteract muscle wasting in conditions like cachexia.
What is Hexarelin?
Hexarelin is a hexapeptide with the sequence His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys. It interacts primarily with the growth hormone secretagogue receptor (GHSR) and CD36 receptor, mediating a range of protective and regenerative actions in cardiac and skeletal muscle tissues. Its molecular formula is C47H58N12O6, and it has a molecular weight of 887.06 g/mol.
Key Effects and Benefits
Heart Protection: Hexarelin binds to cardiac receptors to protect heart cells from apoptosis (programmed cell death) after ischemic injury. Rodent studies indicate improved heart function, reduced scar size after heart attacks, decreased oxidative stress, and prevention of pathological cardiac remodeling that can lead to heart failure.
Lipid Metabolism: Hexarelin improves lipid profiles by correcting dyslipidemia linked to insulin resistance and diabetes risk. It lowers blood sugar and insulin resistance while normalizing cholesterol and triglyceride levels, offering potential benefits for metabolic health.
Muscle Preservation: In models of muscle wasting due to illness or chemotherapy (cachexia), Hexarelin preserves skeletal muscle by regulating calcium homeostasis and mitochondrial function—critical for muscle energy production and preventing muscle atrophy.
Reduction of Oxidative Stress: Hexarelin decreases markers of oxidative damage in cardiac muscle and favors parasympathetic nervous system dominance, contributing to heart health and reduced cardiovascular stress.
Mechanism of Action
Hexarelin activates GHSR and CD36 receptors. Through these pathways, it reduces cellular stress responses, inhibits apoptosis in heart and muscle cells, modulates calcium cycling crucial for muscle contraction, and regulates key signaling pathways involved in cell survival such as PTEN and protein kinase B.
Research Highlights
Prevents myocardial fibrosis and improves heart contractility in ischemic injury models
Reduces the size of cardiac damage scar tissue post-heart attack
Enhances mitochondrial integrity and calcium regulation in skeletal muscle
Corrects dyslipidemia and insulin resistance in rodent diabetes models
Supports autonomic balance favoring parasympathetic activity, which is protective for cardiovascular health
Specifications
Content: 2mg Hexarelin per vial
Sequence: His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys
Molecular Formula: C47H58N12O6
Molecular Weight: 887.06 g/mol
CAS Number: 140703-51-1
Purity: High-purity research grade
Form: Lyophilized powder for laboratory use
Storage: Store in a cool, dry place per research standards
Compliance Disclaimer
Hexarelin 2mg from PeptidesAlpha is sold exclusively for scientific research and laboratory use. It is not approved for human or veterinary consumption and must not be used for any therapeutic, diagnostic, or nutritional purposes. All usage must conform to applicable laws and regulations.
PeptidesAlpha offers high-quality Hexarelin to support advanced cardiovascular and muscle research with trusted purity and reliability.
Hexarelin 2mg
- Typical dosages can range, but commonly it’s 2mg per vial, which can be reconstituted with sterile water.
- The peptide is typically administered via subcutaneous injection.
- The dosing regimen often involves one injection per week, as it has a prolonged half-life (due to the DAC component).
- As with any peptide, there could be risks, such as injection site reactions, water retention, or possible changes in insulin sensitivity.
- It’s important to monitor health regularly and consult with a healthcare provider, especially if using for long-term purposes.