Humanin is a naturally occurring mitochondrial micro-peptide known for its powerful cytoprotective properties. Encoded by mitochondrial DNA, Humanin plays a critical role in protecting cells from apoptosis (programmed cell death) and has been implicated in the prevention and mitigation of various age-related diseases affecting the brain, heart, muscles, and eyes.
What is Humanin?
Humanin is a 24-amino acid peptide (sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala) uniquely encoded in the mitochondrial genome. It interacts primarily by inhibiting the function of pro-apoptotic proteins such as the Bcl-2-associated X protein (Bax), effectively blocking apoptosis and enhancing cellular survival.
Key Research Highlights
Neuroprotection: Humanin protects neurons from apoptosis caused by pathological factors such as beta-amyloid plaques in Alzheimer’s disease and excitotoxicity, offering potential to delay or reduce neurodegenerative disease progression.
Cardiovascular Protection: It reduces oxidative stress and apoptosis in vascular tissues and helps protect against damage from oxidized LDL cholesterol, contributing to improved vascular health and potentially reducing cardiovascular disease risk.
Mitochondrial Function and Aging: Humanin levels decline with age, correlating with increased age-associated cellular dysfunction. Supplementation research suggests it may improve mitochondrial efficiency and offset age-related decline in tissue health.
Retinal Health: Humanin enhances resistance to oxidative damage in retinal pigment epithelial cells, showing promise for age-related macular degeneration and diabetic retinopathy research.
Bone and Cartilage Support: It prevents chondrocyte apoptosis and suppresses excessive osteoclast activity, supporting bone and cartilage integrity, especially significant in conditions involving bone loss such as osteoporosis and glucocorticoid-induced damage.
Interaction with IGF-1: Humanin modulates insulin-like growth factor 1 (IGF-1) signaling, exhibiting both synergistic and antagonistic interactions that impact cell survival, inflammation, and metabolic regulation.
Molecular and Product Details
Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Molecular Formula: C119H204N34O32S2
Molecular Weight: 2687.3 g/mol
CAS Number: 330936-69-1
Synonyms: Formyl Humanin, HNGF6A protein
Purity: High-purity research grade, verified by HPLC
Form: Lyophilized powder
Storage: Store in a cool, dry place following laboratory guidelines
Compliance Disclaimer
Humanin 10mg from PeptidesAlpha is intended solely for in-vitro scientific research and laboratory use. It is not approved for human or animal consumption, medical treatment, diagnosis, or preventative therapy. Usage outside of research contexts is strictly prohibited by law.
PeptidesAlpha provides premium-quality Humanin peptides for advanced cellular and mitochondrial research to support scientific discovery and innovation.