MGF, an isoform of insulin-like growth factor-1 (IGF-1), is known for its potent tissue repair, regeneration, and protective effects. This splice variant, also called IGF-1Eb, plays a critical role in muscle remodeling, wound healing, cardiac repair, and protection of skeletal muscle and cartilage from mechanical stress.
What is MGF?
MGF is generated through alternative splicing of the IGF-1 gene, producing distinct isoforms with unique functions. It is highly upregulated in muscle following injury or exercise, activating satellite cells and promoting muscle growth and regeneration. MGF also supports neuronal survival and combats muscle wasting associated with aging and diseases like ALS.
Key Benefits and Research Highlights
Muscle Repair & Growth: MGF stimulates muscle stem cells (satellite cells), enhancing repair after injury and increasing muscle fiber size. Research in rodents shows significant hypertrophy and improved recovery with MGF administration.
Age-Related Muscle Decline: MGF expression changes with age, potentially contributing to muscle loss. Supplementation may offset age-related muscle atrophy, although further research is ongoing.
Anti-Inflammatory Effects: MGF modulates inflammation via macrophages, which are pivotal in muscle regeneration, potentially accelerating healing processes.
Cartilage Protection and Regeneration: MGF promotes chondrocyte survival and migration, essential for cartilage repair and preventing degenerative diseases like osteoarthritis. It may reduce mechanical-overload induced damage in joints and the spine by inhibiting apoptosis in cartilage cells.
Neuroprotection: MGF is neuroprotective, improving survival and function of neurons in brain injury models and neurodegenerative diseases such as ALS. It supports motor neuron survival and may slow disease progression.
Cardiac Protection: In heart attack models, MGF reduces cardiac cell death and improves heart muscle function, showing promise for acute myocardial infarction treatment by limiting cardiac damage up to 35%.
Molecular and Product Information
Peptide Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
Molecular Formula: C124H204N42O41S
Molecular Weight: 2971.99 g/mol
Synonyms: Mechano-growth factor, IGF-1Eb
Form: Lyophilized powder, research grade
Purity: High purity, suitable for laboratory use
Storage: Store under recommended conditions (cool, dry place)
Research Applications
MGF is actively researched for its potential therapeutic roles in sports medicine, regenerative therapies, neurodegeneration, osteoarthritis, and heart repair. It offers a promising approach to accelerating recovery and protecting tissues from injury-induced degeneration.
Compliance Disclaimer
MGF C-Terminal 5mg from PeptidesAlpha is supplied exclusively for laboratory and research use. It is not approved for human or veterinary consumption, medical use, or diagnostic purposes. Any human or animal administration is prohibited by law.
PeptidesAlpha is your trusted source for premium-quality MGF peptides tailored for advanced scientific and medical research.