Molecular Formula: C₂₇H₃₆N₄O₅S
Molecular Weight: 528.7 g/mol
Chemical Name: 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
Purity: >99%
Capsule Size: 12.5mg per capsule
Bottle Size: 60 capsules
Storage: Room temperature, protect from moisture
Product Overview
MK-677 represents revolutionary growth hormone secretagogue technology designed for comprehensive anti-aging, muscle development, and sleep enhancement research applications. This orally bioactive ghrelin receptor agonist demonstrates exceptional ability to stimulate natural growth hormone secretion and IGF-1 production without affecting cortisol levels or suppressing endogenous hormone production. Unlike synthetic growth hormone injections, MK-677 maintains physiological pulsatile GH release patterns while providing sustained elevation for up to 24 hours from a single dose, making it invaluable for investigating growth hormone axis modulation and age-related decline reversal.
Revolutionary Ghrelin Mimetic Mechanism
MK-677 functions as a potent selective agonist of the ghrelin receptor (GHSR-1a), triggering natural growth hormone release through hypothalamic-pituitary axis activation. The compound stimulates endogenous GH secretion in pulsatile patterns, increasing 24-hour mean GH levels by 1.8-fold and IGF-1 concentrations by 1.5-fold without desensitization or feedback inhibition. This mechanism preserves physiological hormone regulation while enhancing anabolic processes, recovery mechanisms, and metabolic optimization through sustained elevation of growth factors critical for cellular repair and regeneration.
Primary Research Applications
Anti-Aging & Somatopause Studies
Clinical validation demonstrates remarkable ability to reverse age-related GH decline, with elderly subjects achieving IGF-1 levels comparable to healthy young adults. Research shows 2kg body weight increase, enhanced bone mineral density, decreased LDL cholesterol, and improved body composition over 2-year treatment periods. Studies reveal protection against sarcopenia, frailty prevention, and enhanced muscle function in aging populations, positioning MK-677 as breakthrough tool for investigating longevity mechanisms and age-related physical decline reversal.
Sleep Quality & Recovery Research
Comprehensive studies demonstrate unprecedented sleep enhancement with 50% increase in Stage 4 deep sleep duration and 20-50% increase in REM sleep across age groups. Research shows decreased sleep deviations from 42% to 8% in young adults and significantly reduced REM latency in elderly subjects. Applications include investigating sleep-growth hormone relationships, recovery optimization mechanisms, and therapeutic approaches for sleep disorders through natural hormone pathway activation.
Muscle Growth & Body Composition Studies
Research reveals enhanced lean body mass development, improved nitrogen retention during caloric restriction, and reversal of diet-induced catabolism. Studies demonstrate protection against muscle wasting in clinical settings, enhanced protein synthesis, and improved functional outcomes in elderly patients recovering from hip fractures including increased gait speed and reduced fall risk. Applications encompass sarcopenia research, athletic performance enhancement, and muscle preservation during aging or disease states.
Neurological Enhancement Research
Studies demonstrate significant neuroprotective effects including enhanced amyloid beta clearance, reduced neurodegeneration in Alzheimer's models, and improved cognitive function when administered before disease onset. Research shows increased IGF-1 brain penetration, enhanced neuronal survival, and protection against age-related cognitive decline. Applications include investigating neurodegenerative disease prevention, cognitive aging mechanisms, and memory consolidation through sleep-growth hormone optimization.
Cardiovascular & Metabolic Research
Research reveals enhanced endothelial progenitor cell function, improved nitric oxide synthesis, and cardiovascular protection through IGF-1 pathway activation. Studies demonstrate potential for preventing atherosclerosis, reducing cardiac disease risk, and improving vascular health in aging populations. Applications include investigating heart disease prevention, blood pressure regulation, and metabolic syndrome improvement through growth hormone axis modulation.
Mechanism of Action
Ghrelin Receptor Activation: Selective GHSR-1a agonism triggering physiological growth hormone release patterns
IGF-1 Enhancement: Sustained elevation of insulin-like growth factor promoting anabolic and regenerative processes
Sleep Architecture Optimization: Enhanced deep sleep and REM stages critical for recovery and hormone production
Metabolic Acceleration: Improved nitrogen retention, protein synthesis, and fat oxidation capabilities
Appetite Stimulation: Ghrelin-mediated hunger enhancement supporting muscle building and recovery nutrition
Neuroprotection: Enhanced brain-derived growth factor signaling and amyloid clearance mechanisms
Research Advantages
Oral Bioavailability: Convenient once-daily capsule administration with 24-hour duration eliminating injections
No Suppression Risk: Maintains natural hormone production without requiring cycling or post-treatment recovery
Multi-System Benefits: Simultaneous sleep, muscle, cognitive, and metabolic applications in single compound
Clinical Foundation: Extensive human studies confirming safety and efficacy across multiple age groups
Physiological Patterns: Preserves natural pulsatile GH release rather than creating supraphysiological spikes
Long-Term Sustainability: Proven effectiveness for up to 2 years without tolerance or adverse effects
Age-Specific Benefits: Enhanced efficacy in elderly populations with natural hormone decline
Quality Specifications
Every MK-677 capsule batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Molecular weight confirmation at 528.7 g/mol
CAS number validation (159634-47-6)
PubChem CID verification (9939050)
Ghrelin receptor binding affinity assessment
Growth hormone stimulation bioactivity testing
Certificate of Analysis provided with shipment
Storage & Administration
Store capsules at room temperature in sealed bottle. Protect from moisture and excessive heat. Capsules maintain stability for 24 months when stored properly. Each capsule contains precisely measured 12.5mg dose enabling consistent research protocols. Optimal administration timing typically occurs in evening to align with natural growth hormone release patterns during sleep cycles.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.