Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme found in all living cells that plays an essential role in metabolic processes and cellular function. NAD+ cycles between oxidized (NAD+) and reduced (NADH) forms, facilitating electron transfer critical for energy production and sustaining life. It participates in over 500 enzymatic reactions central to maintaining cellular homeostasis and health.
What is NAD+?
NAD+ is a cofactor mediating redox reactions essential for energy metabolism, DNA repair, gene regulation, and cellular communication. It activates enzymes like sirtuins—linked to longevity and the benefits of calorie restriction—and poly-ADP-ribose polymerases (PARPs), which facilitate DNA repair and genomic stability. NAD+ also functions as an extracellular signaling molecule released by neurons in various tissues, influencing processes in blood vessels, the bladder, and the brain.
Key Biological Effects
Energy Metabolism: NAD+ shuttles electrons within cells and mediates energy conversion, supporting mitochondrial function and overall metabolic efficiency.
DNA Repair and Longevity: By activating sirtuins and PARPs, NAD+ promotes genomic stability, DNA repair, and modulates inflammation, which are crucial for aging and disease prevention.
Neuroprotection: NAD+ enhances production of PGC-1-alpha, which protects neurons from oxidative stress. Animal studies link this effect to improved memory and cognitive function with aging.
Cardiovascular Health: NAD+ protects blood vessels from age-related damage, atherosclerosis, and dysfunction of the aorta, potentially reversing age-associated vascular decline.
Muscle Function: Supplementation in animal models has shown increased metabolism, lean body mass, muscle strength, and endurance, especially in aging muscles.
Immune Regulation and Inflammation: NAD+ modulates immune responses and inflammation through interactions with enzymes and regulators like NAMPT, which are involved in metabolic diseases and obesity-related inflammation.
Extracellular Signaling: NAD+ influences smooth muscle function and may benefit gastrointestinal health and blood pressure regulation.
Research and Synergies
NAD+ levels decline with age and disease states, contributing to mitochondrial dysfunction and cellular senescence.
Combination with biotin, CoQ10, resveratrol, and B vitamins may enhance NAD+ effectiveness by supporting antioxidant defenses, neurological protection, and metabolic health.
NAD+ supplementation is a focus of anti-aging research, showing promise in reversing mitochondrial aging and supporting stem cell function.
Studies suggest NAD+ may slow progression or improve symptoms of neurodegenerative diseases like Alzheimer’s and Parkinson’s.
NAD+ supplementation may also aid addiction recovery through effects on cravings, stress, and anxiety when combined with specific amino acids.
Molecular Information
Molecular Formula: C21H27N7O14P2
Molecular Weight: 663.43 g/mol
CAS Number: 53-84-9
Synonyms: Nicotinamide adenine dinucleotide, beta-NAD, NAD, Endopride
Product Details
Content: 750mg NAD+ per vial
Form: High-purity lyophilized powder, research grade
Storage: Store in a cool, dry place protected from light according to laboratory protocols
Compliance Disclaimer
NAD+ 750mg from PeptidesAlpha is strictly for in-vitro laboratory and scientific research. It is not approved for human or animal consumption, medical treatment, or diagnosis. The product is not a drug and is not intended to prevent, treat, or cure any disease. Usage outside controlled research environments is prohibited by law.
PeptidesAlpha provides premium NAD+ peptides to support cutting-edge research in aging, metabolism, neurology, and beyond with guaranteed quality and purity.