PE-22-28 Peptide - Advanced TREK-1 Antagonist for Neurological Research
Molecular Formula: C₃₅H₅₅N₁₁O₉
Molecular Weight: 773.8947 g/mol
Sequence: GVSWGLR
Purity: >99%
Storage: Store at -20°C, protect from light
 
Product Overview
 
PE-22-28 represents a breakthrough synthetic analog of the naturally occurring peptide spadin, specifically engineered for enhanced stability and bioactivity in neurological research applications. This shortened spadin derivative demonstrates superior TREK-1 channel inhibition compared to its natural counterpart, making it an invaluable tool for researchers investigating mood regulation, neurogenesis, and neuroprotection mechanisms.
 
Key Research Applications
 
Neurogenesis & Synaptogenesis Research
PE-22-28 has demonstrated remarkable ability to stimulate both neurogenesis and synaptogenesis in hippocampal tissue within just four days of administration in preclinical studies. Research indicates approximately double the rate of BrdU-positive cell incorporation and synapse formation, significantly faster than traditional interventions.
 
Depression & Mood Disorder Studies
 
As a selective TREK-1 antagonist, PE-22-28 targets two-pore potassium channels primarily located in brain regions controlling mood, memory, and learning including the prefrontal cortex, amygdala, and hippocampus. Studies show effectiveness in reversing depressive symptoms with minimal side effects compared to conventional treatments.
 
Stroke Recovery Research
 
Post-stroke depression research has identified TREK-1 over-expression as a causative factor. PE-22-28's TREK-1 blocking activity makes it valuable for investigating stroke recovery mechanisms and potential neuroprotective interventions.
 
Cognitive Enhancement Studies
 
The hippocampal neurogenesis induced by PE-22-28 suggests potential applications in learning and memory research, positioning it as a valuable tool for nootropic and cognitive enhancement investigations.
 
Alzheimer's & Neurodegeneration Research
 
PE-22-28 increases CREB (cAMP response element-binding protein) activity, a transcription factor crucial for neuronal plasticity and memory formation. CREB downregulation is associated with Alzheimer's disease, making PE-22-28 relevant for neurodegenerative disease research.
Mechanism of Action
PE-22-28 functions as a selective antagonist of TREK-1 (TWIK-related potassium channel) receptors. By blocking these channels, the peptide reduces neuronal excitability thresholds while promoting neuroplasticity. Unlike TREK-1 knockout models that show increased seizure susceptibility, PE-22-28 treatment actually provides neuroprotective effects against excitotoxicity.
Research Advantages
 
Enhanced Stability: Synthetic modifications provide improved half-life and bioavailability compared to natural spadin
 
Rapid Action: Demonstrates neurogenesis effects within 4 days, substantially faster than traditional compounds
 
Selectivity: Specific TREK-1 targeting without significant cross-reactivity with TREK-2, TRAAK, TASK, or TRESK channels
 
Safety Profile: Extensive preclinical studies show minimal side effects compared to conventional alternatives
 
Quality Assurance
 
Every batch of PE-22-28 undergoes rigorous quality control testing including:
HPLC purity analysis (>99% minimum)
Mass spectrometry verification
Endotoxin testing
Sterility assurance
Certificate of Analysis provided with each order
 
Storage & Handling
 
Store lyophilized powder at -20°C in original sealed vials. Protect from light and moisture. Once reconstituted, use immediately or store at -80°C for short-term use. Avoid repeated freeze-thaw cycles. Allow vials to reach room temperature before opening to prevent condensation.
 
Research Applications Summary
Neurogenesis and synaptogenesis studies
Depression and mood disorder research
Stroke recovery investigations
Cognitive enhancement research
Alzheimer's disease studies
Neuroprotection research
TREK-1 channel pharmacology
Hippocampal plasticity studies
 
Regulatory Compliance
 
PE-22-28 is manufactured under strict GMP conditions and is intended solely for laboratory research purposes. This product is not for human consumption, therapeutic use, or clinical application. Researchers should follow institutional guidelines and obtain appropriate approvals for all studies.
Important: This product is for research use only. Not for human or veterinary use. Handle with appropriate laboratory safety protocols.