PEG-MGF (5mg) - Advanced Mechano-Growth Factor for Tissue Repair Research
 
Molecular Formula: C₁₂₁H₂₀₀N₄₂O₃₉
Sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
Purity: >99%
Vial Size: 5mg
Storage: Store at -20°C, protect from light
 
Product Overview
 
PEG-MGF (Pegylated Mechano-Growth Factor) represents a revolutionary advancement in tissue repair research. This modified form of IGF-1 combines the powerful regenerative properties of Mechano-Growth Factor with enhanced stability and bioavailability through PEGylation technology. Unlike standard MGF with its extremely short plasma half-life, PEG-MGF provides extended systemic circulation, making it invaluable for comprehensive tissue repair studies.
 
PEGylation Technology Advantage
 
The polyethylene glycol modification serves dual purposes: dramatically extending plasma half-life and reducing renal clearance. This breakthrough allows researchers to achieve therapeutic concentrations through single systemic administrations rather than multiple direct tissue injections, revolutionizing experimental protocols and enabling whole-body studies previously impossible with native MGF.
 
Primary Research Applications
 
Skeletal Muscle Repair & Hypertrophy
PEG-MGF demonstrates remarkable efficacy in muscle tissue regeneration research. Studies show 25% increases in mean muscle fiber size and enhanced myoblast proliferation. The peptide reduces inflammatory hormone expression, decreases oxidative stress, and improves macrophage recruitment to injury sites, accelerating recovery timelines significantly.
 
Cardiac Tissue Protection
Breakthrough cardiovascular research reveals PEG-MGF's ability to inhibit programmed cardiomyocyte death following hypoxia. Animal studies demonstrate reduced cardiac injury by up to 35% when administered within eight hours post-myocardial infarction. The peptide recruits cardiac stem cells to injury sites and prevents pathologic hypertrophy while preserving contractile function.
 
Bone Regeneration Studies
Research in rabbit models shows accelerated bone repair rates, with PEG-MGF treated subjects achieving six-week healing levels in just four weeks. The peptide stimulates osteoblast proliferation and enhances mineralization processes, offering promising applications for orthopedic research and bone healing studies.
 
Cartilage & Joint Research
PEG-MGF improves chondrocyte function and migration from bone marrow into cartilage tissue. The extended half-life makes it particularly suitable for intra-articular injection studies, where single administrations can provide weeks of localized therapeutic effect for cartilage regeneration research.
 
Neuroprotective Research
Emerging studies indicate PEG-MGF's potential in neurological applications. Research shows reduced age-related neuron degeneration, improved cognitive function retention, and decreased motor neuron loss in ALS models. Brain tissue studies reveal natural MGF overexpression in regions with highest neuronal regeneration rates.
 
Dental & Periodontal Applications
Cell culture studies demonstrate enhanced osteogenic differentiation in human periodontal ligament cells, with increased MMP-1 and MMP-2 expression. This suggests potential applications in tooth preservation research and periodontal regeneration studies.
 
Mechanism of Action
 
PEG-MGF functions as a potent IGF-1 receptor agonist, stimulating this receptor pathway equally to native IGF-1. Activation triggers multiple anabolic cascades including:
Enhanced protein synthesis and muscle hypertrophy
Accelerated wound healing and tissue repair
Improved cellular migration and proliferation
Reduced inflammatory responses
Enhanced stem cell recruitment and activation
Increased metabolic efficiency and fat oxidation
The PEGylation modification extends plasma circulation time from minutes to hours, enabling systemic distribution and sustained tissue exposure impossible with native MGF.
Research Benefits
 
Extended Activity: Hours vs. minutes of therapeutic window
Systemic Distribution: Single injection reaches multiple tissue types
Enhanced Stability: Resistant to proteolytic degradation
Reduced Dosing Frequency: Less frequent administrations needed
Improved Bioavailability: Superior subcutaneous absorption
Minimal Side Effects: Excellent safety profile in preclinical studies
 
Quality Specifications
Every PEG-MGF batch undergoes comprehensive quality control:
HPLC purity analysis confirming >99% purity
Mass spectrometry molecular weight verification
Endotoxin testing (<1.0 EU/mg)
Sterility testing via USP standards
Certificate of Analysis included with shipment
Lyophilized powder stability testing
 
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with bacteriostatic water or sterile saline immediately before use. Once reconstituted, use within 24 hours or store at -80°C for up to one week. Avoid repeated freeze-thaw cycles.
 
Dosage Considerations for Research
Preclinical studies utilize various dosing protocols depending on research objectives:
Muscle repair studies: Direct injection or systemic administration
Cardiac protection: Early intervention within 8-hour window optimal
Bone healing: Localized delivery or systemic dosing effective
Neurological research: Chronic dosing protocols show enhanced benefits
 
Research Applications Summary
Muscle hypertrophy and repair studies
Cardiovascular protection research
Bone and cartilage regeneration
Neuroprotective mechanism studies
Wound healing research
Anti-aging and metabolic studies
Stem cell mobilization research
Athletic performance enhancement studies
Regulatory Compliance
PEG-MGF is manufactured under strict GMP conditions specifically for research applications. This product is exclusively intended for laboratory research use and is not approved for human consumption, therapeutic applications, or clinical use. Researchers must comply with institutional guidelines and obtain appropriate ethics approvals.
 
Research Use Only: Not for human or veterinary therapeutic use. Handle according to laboratory safety protocols and institutional guidelines.