Molecular Formula: C₁₅H₂₆N₆O₈
Sequence: Glu-Asp-Arg (EDR)
Molecular Weight: 418.407 g/mol
Synonyms: Glutamylaspartylarginine, T-33 peptide
Purity: >99%
Vial Size: 20mg
Storage: Store at -20°C, protect from light
Product Overview
Pinealon represents a paradigm shift in peptide bioregulator research as one of the few synthetic peptides proven to interact directly with DNA. This revolutionary tripeptide bypasses traditional receptor-mediated mechanisms, penetrating both cellular and nuclear membranes to regulate gene expression at the most fundamental level. Pinealon's unique mechanism makes it invaluable for researchers investigating aging, neuroprotection, circadian rhythm regulation, and cellular regeneration.
Unique DNA-Interactive Mechanism
Unlike conventional peptides that bind to surface or cytoplasmic receptors, Pinealon's compact three-amino-acid structure enables direct nuclear penetration and DNA interaction. HeLa cell studies confirm the peptide's ability to cross lipid bilayers, including both cellular and nuclear membranes, to directly modulate gene expression patterns. This unprecedented mechanism classifies Pinealon as a true bioregulator capable of epigenetic modifications that influence multiple physiological systems.
Primary Research Applications
Anti-Aging & Longevity Research
Russian studies demonstrate Pinealon's remarkable anti-aging effects, particularly in central nervous system tissue. The peptide slows biological aging rates when measured against established biomarkers. Research indicates Pinealon works synergistically with similar bioregulators to produce anabolic effects in brain tissue, offering unprecedented applications in longevity research.
Neuroprotection & Cognitive Enhancement
Pinealon provides robust neuronal protection against oxidative stress and hypoxic conditions. Prenatal rat studies show marked reductions in reactive oxygen species accumulation and necrotic cell death in brain tissue. The peptide enhances cognitive function and motor coordination while protecting against neurodegenerative processes. Adult studies confirm increased neuronal resistance to hypoxic stress through stimulation of antioxidative enzyme systems.
Depression & Serotonin Research
Groundbreaking research reveals Pinealon's ability to boost 5-tryptophan hydroxylase expression through epigenetic modifications. This enzyme is critical for serotonin production and secretion, positioning Pinealon as a natural alternative to SSRIs for depression research. The peptide offers potential for more physiological approaches to mood regulation with reduced side effect profiles.
Circadian Rhythm & Sleep Studies
Pinealon directly affects pineal gland function, making it invaluable for circadian rhythm research. Studies show the peptide can reset disrupted sleep-wake cycles caused by shift work or long-distance travel. Research indicates improvements in sleep quality, mood regulation, blood pressure, and overall circadian function through pineal gland baseline restoration.
Irisin Expression & Metabolic Research
Pinealon significantly alters irisin expression in muscle and brain tissue. Irisin protects muscle cells during exercise, promotes fat oxidation, and induces telomere elongation. Brain irisin levels stimulate hippocampal genes crucial for memory, learning, and neuronal health. This positions Pinealon as a bridge between exercise physiology and cognitive function research.
Cardiovascular Protection Studies
Research in myocardial infarction models shows Pinealon reduces cardiac injury by up to 35% when administered within eight hours post-event. The peptide suppresses caspase-3 mediated apoptosis, preventing long-term cardiac remodeling and preserving contractile function. Applications extend to both acute treatment protocols and preventive cardioprotection research.
Cellular Protection Mechanisms
Caspase-3 Inhibition
Pinealon modulates cytokine signaling pathways that normally increase caspase-3 enzyme levels. By suppressing this apoptosis initiator, the peptide provides universal cellular protection across tissue types. Benefits extend from neurological tissue to cardiac muscle and dermal cells, offering broad applications in cell death prevention research.
Cell Cycle Modulation
Under oxidative stress conditions, Pinealon activates proliferation pathways that offset reactive oxygen species damage. This cell cycle modification represents a sophisticated cellular defense mechanism that maintains tissue integrity during pathological conditions. The effect is particularly pronounced in neurological tissue where cell replacement is limited.
Oxidative Stress Protection
Studies demonstrate significant reductions in reactive oxygen species accumulation with Pinealon treatment. The peptide enhances innate antioxidative enzyme systems while limiting excitotoxic effects of N-methyl-D-aspartate (NMDA). This dual protection mechanism makes it valuable for stroke, traumatic brain injury, and neurodegenerative disease research.
Regenerative Applications
Skin Regeneration Research
Pinealon promotes cellular proliferation in both young and aged skin models by reducing apoptosis rates. Studies show increased regenerative processes that offset age-related dermal pathology. Applications span from wound healing research to potential sun protection and burn treatment studies.
Telomere Protection
Through irisin expression enhancement, Pinealon extends telomere protection mechanisms. Plasma irisin levels correlate directly with telomere length in healthy adults and link to calorie restriction pathways known to extend lifespan. This positions Pinealon at the forefront of cellular aging research.
Research Advantages
Direct DNA Interaction: Unique mechanism bypassing receptor limitations
Multi-System Effects: Single compound affecting neurological, cardiac, metabolic, and dermal systems
Epigenetic Modulation: True gene expression regulation capabilities
Minimal Side Effects: Excellent safety profile across preclinical studies
High Bioavailability: Superior subcutaneous and oral absorption
Universal Protection: Broad spectrum cellular protection mechanisms
 
Storage & Handling
Store lyophilized powder at -20°C in original sealed containers. Protect from light, heat, and moisture. Reconstitute with bacteriostatic water immediately before use. Once reconstituted, use within 24 hours or store at -80°C for short-term use. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
 
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.