Molecular Formula: C₃₃H₅₇N₁₁O₉
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Weight: 751.887 g/mol
PubChem CID: 11765600 | CAS Number: 129954-34-3
Purity: >99% | Vial Size: 10mg | Storage: -20°C, protect from light
 
Product Overview
Selank represents a breakthrough synthetic analog of naturally occurring tuftsin with profound nootropic and anxiolytic properties. This Russian-developed heptapeptide incorporates four additional amino acids beyond natural tuftsin, significantly enhancing metabolic stability and extending half-life. Selank offers researchers unique tools for investigating anxiety disorders, cognitive enhancement, immune modulation, and pain management through novel GABA-ergic and enkephalin-mediated pathways.
Revolutionary Dual-Mechanism Action
Selank functions through two primary mechanisms: direct modulation of GABA receptor gene expression and inhibition of enkephalin-degrading enzymes. Unlike conventional benzodiazepines that bind GABA receptors, Selank alters receptor affinity by changing gene expression patterns. The peptide influences 52 of 84 known GABA-related genes, with seven showing heavy modulation. Additionally, Selank protects natural enkephalins from degradation, preserving the body's endogenous anxiolytic and analgesic peptides.
Primary Research Applications
Anxiety & Stress Research
Clinical studies demonstrate Selank's exceptional anti-anxiety efficacy comparable to benzodiazepines without addiction potential or withdrawal symptoms. Research shows effective treatment of generalized anxiety disorder and anxiety-asthenic conditions involving fatigue, headache, palpitations, and nerve pain. Unlike traditional anxiolytics, Selank provides synergistic effects when combined with benzodiazepines while offering superior outcomes in unpredictable chronic mild stress conditions.
Cognitive Enhancement Studies
Selank demonstrates direct memory and learning enhancement beyond simple anxiety reduction. Rat studies reveal improved memory trace stability and enhanced storage processes regardless of baseline anxiety levels. The peptide modulates 36 hippocampal genes encoding plasma membrane proteins, facilitating ion-dependent learning and memory processes. Research indicates potential for cognitive rescue following traumatic brain injury through catecholamine system modulation.
Immune System Modulation
Selank exhibits complex immunomodulatory effects, regulating 34 inflammation-related genes affecting chemokines, cytokines, and their receptors. In depression patients, the peptide suppresses IL-6 inflammatory cytokine production without affecting healthy individuals, suggesting selective therapeutic targeting. Studies reveal modulation of BcI6 gene expression critical for immune system development and altered splenic gene expression affecting immune balance.
Pain Management Research
Through enkephalinase inhibition, Selank extends the half-life of natural enkephalins - endogenous opioid peptides that bind pain receptors. Research shows elevated enkephalinase activity in anxiety/phobic disorders, with Selank potentially resetting this enzymatic pathway. The peptide's ability to preserve natural pain-killing mechanisms offers advantages over synthetic opioids without addiction potential.
Neuroprotection Studies
Selank demonstrates neuroprotective capabilities through BDNF (brain-derived neurotrophic factor) modulation and anti-inflammatory effects. The peptide influences T-helper cells and monoamine neurotransmitters while providing protection against stress-induced neuronal damage. Research suggests potential applications in neurodegenerative conditions through multiple protective pathways.
Mechanisms of Action
GABA System: Modulates 52 GABA-related genes, alters receptor affinity
Enkephalin Protection: Inhibits degrading enzymes, extends natural analgesic peptides
Gene Expression: Influences hippocampal and inflammatory pathway genes
Neurotransmitter Modulation: Affects monoamine systems and BDNF expression
Immune Regulation: Selective cytokine suppression in pathological states
Research Advantages
Non-Addictive: No withdrawal symptoms or tolerance development
Dual Benefits: Combined anxiolytic and cognitive enhancement effects
Selective Action: Targets pathological states while sparing healthy function
Gene-Level Effects: Direct transcriptional modification capabilities
Multi-System Impact: Anxiety, cognition, immune, and pain pathways
Synergistic Potential: Enhanced effects with conventional treatments
Excellent Safety Profile: Minimal side effects in clinical studies
Clinical Research Evidence
Studies demonstrate Selank's efficacy across multiple domains:
Anxiety reduction comparable to benzodiazepines
Memory enhancement independent of stress reduction
Selective immune modulation in diseased states
Pain relief through natural opioid preservation
Cognitive rescue following brain injury
Improved outcomes in chronic stress conditions
Quality Specifications
Every Selank batch undergoes comprehensive quality control:
HPLC purity analysis confirming >99% purity
Mass spectrometry molecular weight verification (751.887 g/mol)
Amino acid sequence confirmation (TKLPRPGP)
Endotoxin testing (<1.0 EU/mg)
USP sterility testing standards
Bioactivity assays for GABA receptor modulation
Certificate of Analysis provided with shipment
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with bacteriostatic water immediately before use. Once reconstituted, use within 24 hours or store at -80°C short-term. Avoid repeated freeze-thaw cycles to maintain gene-modulating activity.
Research Protocol Applications
Anxiety and stress disorder mechanism studies
Cognitive enhancement and memory research
Immune system modulation investigations
Pain management and enkephalin pathway studies
Neuroprotection and brain injury research
Gene expression and epigenetic studies
Combination therapy optimization
Behavioral pharmacology research
Bioavailability & Administration
Research demonstrates excellent subcutaneous bioavailability and acceptable intranasal administration routes. The peptide maintains stability sufficient for CNS penetration and gene expression modulation. Multiple administration protocols have proven effective depending on research objectives and target systems.
 
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.