Unlock the remarkable potential of cognitive enhancement and neuroprotection research with our premium Semax peptide. As a synthetic heptapeptide analog of adrenocorticotropic hormone fragments 4-10, Semax represents a breakthrough in neuroscience research, offering unprecedented opportunities to investigate learning, memory, stroke recovery, and neuroplasticity across diverse research applications.
Research Applications & Mechanisms:
Semax operates through sophisticated multi-target mechanisms, primarily by binding to specific melanocortin receptors in the central nervous system and rapidly upregulating brain-derived neurotrophic factor expression. This unique dual approach stimulates neuroplasticity while providing robust neuroprotection, making it invaluable for research into:
Cognitive Enhancement Studies: Investigation of learning, memory consolidation, and information processing mechanisms
Stroke Recovery Research: Exploring ischemia-reperfusion injury protection and functional neurological recovery pathways
Neurodegenerative Disease Models: Understanding neuroprotective mechanisms in Alzheimer's, Parkinson's, and other degenerative conditions
Neuroplasticity Research: Studying synaptic plasticity, neurogenesis, and brain adaptation mechanisms
Depression and Anxiety Studies: Investigating mood regulation through neurotransmitter system modulation
Traumatic Brain Injury Research: Exploring neural protection and recovery following brain trauma
Default Mode Network Studies: Research into resting-state brain connectivity and social cognition
Advanced Research Benefits:
Our Semax peptide demonstrates exceptional research utility through its ability to rapidly increase BDNF protein levels by up to 1.4-fold while simultaneously enhancing TrkB receptor phosphorylation and expression in the hippocampus. Studies indicate that Semax activates transcription of 24 different genes related to vascular function in the brain, promoting neuronal survival, mitochondrial stabilization, and enhanced nutritional supply to neural tissues.
The peptide's influence extends to neurotransmitter systems, including modulation of serotonin, dopamine, and norepinephrine pathways. Research demonstrates that Semax enhances striatal dopamine release while promoting GABA and glycine-activated ionic currents in isolated neurons. This multi-neurotransmitter approach provides comprehensive research applications for investigating cognitive function and mood regulation.
Semax uniquely activates the default mode network, a critical brain system responsible for environmental monitoring and social cognition. This activation correlates with enhanced brain interconnectivity, improved attention, and greater readiness to shift from resting states to focused cognitive tasks, making it invaluable for attention and social neuroscience research.
Neuroprotective Research Applications:
In stroke research models, Semax demonstrates remarkable neuroprotective properties by suppressing inflammatory gene expression while activating neurotransmission-related genes. The peptide's ability to counteract ischemia-reperfusion damage includes downregulation of matrix metalloproteinase-9, c-Fos, and active JNK while upregulating CREB in subcortical structures.
Research indicates that Semax promotes angiogenesis through enhanced endothelial cell migration, smooth muscle cell development, and blood vessel stabilization. These vascular effects contribute to improved cerebral circulation and tissue repair, making it essential for cerebrovascular research applications.
Cognitive Performance Research:
Semax research extends to epilepsy models, where studies demonstrate its ability to protect learning and memory function through BDNF pathway activation. The peptide's effects on gene expression occur within 20 minutes of administration, particularly affecting nerve growth factor and BDNF in both hippocampus and frontal cortex regions critical for executive function.
Research applications include investigation of antidepressant mechanisms, as Semax may enhance SSRI efficacy through BDNF stimulation and neurogenesis promotion. This research foundation supports studies into novel treatment approaches for mood disorders.
Quality Specifications:
Purity: >98% by analytical HPLC-MS
Molecular Weight: 854.99 g/mol
Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula: C39H54N10O10S
CAS Number: 80714-61-0
Alternative Names: ACTH(4-7)-PGP, Pro-Gly-Pro-ACTH
Appearance: White to off-white lyophilized powder
Storage: -20°C for optimal long-term stability
Solubility: Readily soluble in water and physiological buffers
Half-life: Intranasal administration provides optimal bioavailability
Technical Specifications:
pH Range: 4-6 when reconstituted in sterile water
Osmolality: Compatible with physiological conditions
Endotoxin Level: <0.1 EU/mg
Storage Buffer: Lyophilized from acetate buffer system
Reconstitution: Sterile water or appropriate buffer solutions
Binding Affinity: KD = 2.4 ± 1.0 nM for specific binding sites
Important Research Notice:
This product is intended for research use only. Not for human consumption, therapeutic use, or diagnostic applications. Proper institutional oversight and safety protocols should be maintained when conducting neurological research with this material.
Advance your cognitive and neuroprotection research with confidence using our premium Semax peptide - where neurological precision meets research innovation.