SLU-PP-332 Research Compound - Product Description
Molecular Formula: C₂₄H₂₁N₃O₄
Molecular Weight: 415.44 g/mol
Chemical Name: Estrogen-related receptor pan-agonist
Purity: >99%
Capsule Size: 250mcg per capsule
Bottle Size: 60 capsules
Storage: Room temperature, protect from moisture
Product Overview
SLU-PP-332 represents revolutionary exercise mimetic technology designed for comprehensive metabolic, obesity, and energy expenditure research applications. This synthetic estrogen-related receptor agonist demonstrates exceptional ability to activate ERRα, ERRβ, and ERRγ nuclear receptors simultaneously, triggering exercise-induced metabolic adaptations without physical activity. Unlike traditional weight-loss compounds, SLU-PP-332 enhances mitochondrial biogenesis, fatty acid oxidation, and energy expenditure through direct activation of cellular exercise pathways, making it invaluable for investigating metabolic syndrome, obesity, and diabetes mechanisms.
Revolutionary Exercise Mimetic Mechanism
SLU-PP-332 functions as a potent pan-ERR agonist with highest affinity for ERRα (EC₅₀ = 98 nM), activating transcriptional programs normally triggered by endurance exercise. The compound enhances mitochondrial biogenesis through PGC-1α coactivator recruitment, upregulates pyruvate dehydrogenase kinase 4 expression, and stimulates fatty acid oxidation pathways. This mechanism shifts whole-body metabolism toward lipid utilization, increases energy expenditure by 25%, and promotes skeletal muscle oxidative fiber formation while enhancing exercise endurance capacity by up to 70%.
Primary Research Applications
Obesity & Weight Management Studies
Clinical validation demonstrates remarkable 12% body weight reduction in diet-induced obese mice over 28 days with 10-fold less fat accumulation compared to controls. Research shows enhanced fatty acid oxidation, decreased respiratory exchange ratio indicating lipid preference, and significant fat mass reduction without appetite suppression. Applications include investigating obesity mechanisms, metabolic syndrome pathways, and novel weight-loss therapeutic approaches through exercise pathway activation.
Diabetes & Metabolic Syndrome Research
Studies reveal improved glucose tolerance, enhanced insulin sensitivity, and reduced fasting glucose/insulin levels in multiple obesity models including ob/ob and diet-induced obese mice. Research demonstrates decreased hepatic triglycerides, improved lipid profiles with reduced total cholesterol, and enhanced muscle glucose uptake. Applications encompass type 2 diabetes research, insulin resistance mechanisms, and metabolic optimization strategies.
Exercise Performance Enhancement Studies
Research demonstrates 70% increased running duration and 45% greater running distance in normal-weight mice through activation of acute aerobic exercise genetic programs. Studies show upregulation of DDIT4 and other exercise-responsive genes, enhanced mitochondrial respiration in skeletal muscle, and increased oxidative muscle fiber composition. Applications include investigating exercise adaptation mechanisms, endurance enhancement pathways, and athletic performance optimization.
Cardiovascular & Metabolic Health Research
Studies reveal improved heart function in heart failure models through enhanced cardiac fatty acid oxidation and mitochondrial metabolism. Research demonstrates reduced plasma triglycerides, improved cholesterol profiles, and enhanced cardiovascular protection through ERR activation. Applications include investigating cardiac metabolism, heart failure prevention, and cardiovascular disease mechanisms through metabolic pathway modulation.
Anti-Aging & Longevity Studies
Research shows enhanced mitochondrial function, improved cellular respiration, and activation of longevity-associated metabolic pathways. Studies demonstrate potential applications in treating age-related metabolic decline, cognitive dysfunction, and cellular energy deficits. Applications encompass investigating aging mechanisms, mitochondrial health, and longevity enhancement strategies through metabolic optimization.
Mechanism of Action
ERR Receptor Activation: Pan-agonist activity at ERRα/β/γ triggering exercise-induced transcriptional programs
Mitochondrial Enhancement: PGC-1α-mediated biogenesis and enhanced cellular respiration
Fatty Acid Oxidation: Preferential lipid utilization over carbohydrate metabolism
Energy Expenditure: 25% increase in whole-body energy consumption without appetite changes
Exercise Gene Programs: Activation of DDIT4 and exercise-responsive genetic pathways
Metabolic Flexibility: Enhanced ability to switch between fuel sources for optimal efficiency
Research Advantages
Exercise Mimetic Activity: Reproduces exercise benefits without physical activity requirements
Multi-Target Effects: Simultaneous obesity, diabetes, cardiovascular, and performance applications
No Appetite Suppression: Weight loss through metabolic enhancement rather than caloric restriction
Oral Bioavailability: Convenient capsule administration eliminating injection procedures
Safety Profile: No significant adverse effects observed in extensive preclinical studies
Dose-Dependent Response: Scalable effects allowing precise research protocol optimization
Multi-Model Efficacy: Proven effectiveness across multiple obesity and metabolic disease models
Quality Specifications
Every SLU-PP-332 capsule batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Molecular weight confirmation at 415.44 g/mol
ERR receptor binding affinity assessment
CAS number validation (pending official registration)
Endotoxin testing (<0.1 EU/mg)
Exercise mimetic bioactivity validation
Certificate of Analysis provided with shipment
Storage & Administration
Store capsules at room temperature in sealed bottle. Protect from moisture and excessive heat. Capsules maintain stability for 24 months when stored properly. Each capsule contains precisely measured 250mcg dose enabling consistent research protocols. For research applications, capsules may be administered twice daily to achieve optimal metabolic effects observed in preclinical studies.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.