Molecular Formula: C₁₆H₁₉N₃O₅
Molecular Weight: 333.34 g/mol
Sequence: Glu-Trp (EW)
Purity: >99%
Vial Size: 20mg
Storage: -20°C, protect from light
Product Overview
Thymagen represents advanced bioregulatory peptide technology designed for comprehensive immune system, anti-aging, and regenerative medicine research applications. This Khavinson-developed dipeptide demonstrates unique ability to modulate immune cell function through direct interaction with T-lymphocyte development pathways and cyclic nucleotide regulation. Originally isolated from calf thymus and now synthesized via recombinant DNA techniques, Thymagen offers researchers unprecedented opportunities to investigate immune regulation, cellular regeneration, and longevity mechanisms.
Revolutionary Immune Mechanism
Thymagen functions as a specialized thymic bioregulator, directly influencing T-lymphocyte precursor maturation into immunocompetent T-cells through cyclic nucleotide pathway modulation. The peptide down-regulates cyclic nucleotide catabolism, effectively increasing intracellular cAMP and cGMP levels to enhance immune cell responsiveness. This mechanism promotes interferon secretion, stimulates natural killer cell activity, and optimizes immune surveillance capabilities while preventing autoimmune reactions.
Primary Research Applications
Cancer Prevention Research
Comprehensive studies demonstrate Thymagen's ability to reduce tumor incidence by 50% while decreasing malignant tumor development by 70% in experimental models. Research shows enhanced immune surveillance against radiation-induced carcinogenesis with extended survival rates. Applications include investigating natural killer cell mechanisms, immune system cancer surveillance, and tumor suppression pathways.
Cardiovascular Protection Studies
Clinical research reveals significant cardioprotective effects through anti-arrhythmic properties and ischemia-reperfusion injury prevention. Studies demonstrate superior protective capabilities compared to conventional drugs like verapamil in isolated heart models. Research applications encompass cardiac ischemia protection, arrhythmia prevention, and myocardial injury recovery mechanisms.
Immune System Enhancement
Research demonstrates Thymagen's capacity to normalize lymphocyte counts, increase T-cell functional activity, and stimulate cellular immunity responses. Studies show enhanced resistance to bacterial infections, improved humoral antibody responses, and reduced inflammatory cytokine levels. Applications include immunodeficiency research, infection resistance studies, and immune aging investigations.
Diabetes Complications Research
Clinical studies reveal 95% efficacy in correcting secondary immunodeficiency associated with type 1 diabetes. Research demonstrates improved candidiasis resistance and enhanced immune function in diabetic models. Applications encompass diabetic immunocompromise studies, fungal infection resistance research, and metabolic-immune interactions.
Surgical Recovery Research
Studies demonstrate reduced post-operative complications, accelerated healing rates, and decreased infection risks when administered pre-operatively. Research shows shortened recovery periods and enhanced immune function during vulnerable perioperative phases, particularly in elderly populations.
Mechanism of Action
Cyclic Nucleotide Regulation: Enhanced cAMP/cGMP levels improving cellular signaling pathways
T-Cell Maturation: Direct promotion of lymphocyte precursor differentiation into functional immune cells
Interferon Stimulation: Increased production of antiviral and immune regulatory signaling proteins
Inflammatory Modulation: Normalized lymphocyte counts with reduced pro-inflammatory cytokines
Natural Killer Enhancement: Boosted innate immune surveillance against pathogens and malignancies
Anti-Aging Effects: Cellular regeneration promotion and senescence prevention mechanisms
Research Advantages
Dual-Target Action: Simultaneously enhances immune function while providing tissue protection
Clinical Validation: Extensive human studies confirming safety and efficacy profiles
Multi-System Benefits: Immune, cardiovascular, metabolic, and regenerative applications
No Side Effects: Well-tolerated bioregulatory approach with minimal adverse reactions
Geroprotective Properties: Demonstrated life extension and healthy aging capabilities
Tissue-Specific Accumulation: Concentrates in liver, thymus, lymph nodes for targeted effects
Anti-Infection Properties: Enhanced resistance to viral, bacterial, and fungal pathogens
Quality Specifications
Every Thymagen batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Amino acid sequence verification (Glu-Trp)
Molecular weight confirmation at 333.34 g/mol
CAS number validation (38101-59-6)
Endotoxin testing (<0.1 EU/mg)
Bioactivity assays using immune cell lines
Certificate of Analysis provided with shipment
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with bacteriostatic water immediately before use. Once reconstituted, use within 24 hours or store at -80°C for short-term applications. Avoid repeated freeze-thaw cycles to maintain immune-modulating potency and biological activity.
Research Protocol Applications
Immune system enhancement and T-cell development studies
Cancer prevention and tumor suppression mechanism research
Cardiovascular protection and anti-arrhythmic investigations
Diabetes complications and immunocompromise studies
Surgical recovery and wound healing research
Anti-aging and longevity mechanism investigations
Infection resistance and antimicrobial immunity studies
Inflammatory modulation and autoimmune research
Clinical Translation Potential
Thymagen research benefits from four decades of investigation by Professor Vladimir Khavinson with extensive validation in clinical applications. The peptide's proven mechanisms in immune enhancement, cancer prevention, and cardiovascular protection provide robust foundation for investigating novel therapeutic applications in immunodeficiency disorders, age-related diseases, and regenerative medicine interventions.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.
Thymagen 20mg
Typical research protocols: 5-10μg daily for immune enhancement studies
Reconstitute with sterile bacteriostatic water
Administration methods: Subcutaneous injection or cell culture applications
Monitor for immune response markers and T-cell differentiation
Regular cytokine and lymphocyte monitoring during extended protocols
Follow institutional guidelines for immunomodulatory peptide research procedures