Molecular Formula: C₃₃H₅₄N₁₂O₁₅
Molecular Weight: 858.864 g/mol
Sequence: Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
Purity: >99%
Vial Size: 20mg
Storage: -20°C, protect from light
Product Overview
Thymalin represents revolutionary zinc-dependent bioregulatory peptide technology designed for comprehensive immune system, anti-aging, and regenerative medicine research applications. This synthetic version of thymulin, originally isolated from thymus tissue in 1977, demonstrates exceptional ability to modulate T-cell differentiation, enhance immune surveillance, and promote cellular regeneration through direct interaction with thymic epithelial pathways. Unlike broad immunosuppressants, Thymalin specifically restores immune balance while maintaining physiological homeostasis.
Revolutionary Thymic Mechanism
Thymalin functions as a zinc-dependent metallopeptide hormone produced by thymic epithelial cells, requiring equimolar zinc interaction for biological activity. The peptide induces intra- and extra-thymic T-cell differentiation through complex mechanisms involving cyclic nucleotide modulation, cytokine regulation, and direct effects on lymphocyte subpopulations. This unique zinc dependency creates specific three-dimensional conformation essential for receptor binding and immunomodulatory activity.
Primary Research Applications
Life Extension Research
Clinical validation demonstrates 2-fold reduction in mortality rates with significant improvements in cardiovascular, immune, and nervous system function in elderly populations. Studies show decreased acute respiratory disease, hypertension, osteoporosis, and ischemic heart disease incidence. When combined with epithalamin, mortality reduction increases to 4-fold, positioning it as powerful tool for longevity mechanism investigations.
COVID-19 & Viral Infection Studies
Recent clinical trials demonstrate 50% reduction in hospital mortality for severe COVID-19 patients through immune function restoration and cytokine storm prevention. Research shows enhanced lymphocyte recovery, reduced C-reactive protein levels, and improved NK cell activity. Applications include investigating viral clearance mechanisms, immune exhaustion reversal, and antiviral combination therapy optimization.
Cancer Research
Studies demonstrate 80% tumor growth arrest rates with 50% tumor regression in experimental models. Research shows enhanced immune surveillance, increased antibody-producing spleen cells, and improved remission rates when combined with conventional treatments. Applications include investigating tumor immunology, cancer vaccine development, and immune system activation against metastases.
Immune System Enhancement
Comprehensive research reveals normalized lymphocyte counts, increased T-cell functional activity, and stimulated cellular immunity responses. Studies demonstrate enhanced resistance to bacterial infections, improved humoral antibody responses, and reduced inflammatory cytokine levels. Applications encompass immunodeficiency research, infection resistance studies, and immune aging investigations.
Cardiovascular Protection Studies
Research demonstrates reduced lipid levels, normalized T-cell suppressor activity, and direct effects on lymphocytes responsible for plaque removal from arterial walls. Studies show prevention and reversal of atherosclerosis through immune dysfunction correction, positioning it as valuable tool for heart disease mechanism research.
Mechanism of Action
T-Cell Differentiation: Direct promotion of thymic T-cell maturation and functional enhancement
Zinc-Dependent Activity: Metallopeptide formation creating specific receptor binding conformation
Cyclic Nucleotide Modulation: Increased cAMP and cGMP levels enhancing immune cell responsiveness
Inflammatory Regulation: Normalized cytokine production with reduced pro-inflammatory mediators
Cellular Immunity: Enhanced phagocytosis, antibody production, and pathogen resistance
Regenerative Effects: Stimulated hematopoiesis and tissue repair mechanisms
Research Advantages
Clinical Validation: Extensive human studies with proven safety and efficacy across multiple conditions
Multi-System Benefits: Immune, cardiovascular, metabolic, and regenerative applications
Zinc-Dependent Specificity: Unique metallopeptide structure ensuring targeted biological activity
Life Extension Properties: Demonstrated mortality reduction and healthy aging promotion
Minimal Side Effects: Well-tolerated bioregulatory approach with established safety profile
Broad Applications: Effective across viral infections, cancer, autoimmune conditions, and aging research
Synergistic Effects: Enhanced efficacy when combined with other bioregulatory peptides
Quality Specifications
Every Thymalin batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Complete amino acid sequence verification
Molecular weight confirmation at 858.864 g/mol
CAS number validation (63958-90-7)
Zinc binding capacity assessment
Endotoxin testing (<0.1 EU/mg)
Bioactivity assays using immune cell differentiation protocols
Certificate of Analysis provided with shipment
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with sterile bacteriostatic water containing appropriate zinc supplementation immediately before use. Once reconstituted, use within 24 hours or store at -80°C for short-term applications. Avoid repeated freeze-thaw cycles to maintain zinc binding affinity and immunomodulatory potency.
Research Protocol Applications
Immune system enhancement and T-cell differentiation studies
Life extension and anti-aging mechanism investigations
Viral infection treatment and immune restoration research
Cancer immunotherapy and tumor suppression studies
Cardiovascular disease prevention and atherosclerosis research
Post-operative recovery and infection prevention studies
Autoimmune disease and inflammatory modulation research
Stem cell differentiation and regenerative medicine investigations
Clinical Translation Potential
Thymalin benefits from four decades of investigation by Professor Vladimir Khavinson with extensive validation in clinical applications worldwide. The peptide's proven mechanisms in immune enhancement, life extension, and disease treatment provide unparalleled foundation for investigating novel therapeutic applications in immunodeficiency disorders, oncology, and regenerative medicine.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.