Molecular Formula: C₂₀H₃₃N₅O₉
Molecular Weight: 487.5 g/mol
Sequence: Ac-Ser-Asp-Lys-Pro
Purity: >99%
Capsule Size: 500mcg per capsule
Bottle Size: 60 capsules
Storage: Room temperature, protect from moisture
Product Overview
Thymosin Beta-4 Fragment (Ac-SDKP) represents revolutionary anti-inflammatory peptide technology designed for comprehensive cardiovascular, pulmonary, and tissue repair research applications. This naturally occurring tetrapeptide, derived from the N-terminal sequence of thymosin β4, demonstrates exceptional ability to prevent fibrosis, reduce inflammation, and promote angiogenesis through multiple pathway modulation. Unlike broad anti-inflammatory agents, Ac-SDKP specifically targets macrophage activity and TGF-β signaling while maintaining physiological tissue repair mechanisms.
Revolutionary Anti-Fibrotic Mechanism
Ac-SDKP functions as a potent inhibitor of tissue fibrosis through multiple complementary pathways including suppression of transforming growth factor-β, inhibition of myofibroblast differentiation, and modulation of macrophage activation. The peptide preferentially degrades via angiotensin-converting enzyme, creating a unique therapeutic relationship where ACE inhibitors increase Ac-SDKP levels while Ac-SDKP mediates many beneficial effects of ACE inhibition. This dual mechanism provides comprehensive protection against organ damage in cardiovascular, renal, and pulmonary systems.
Primary Research Applications
Cardiovascular Protection Studies
Extensive clinical validation demonstrates significant reduction in cardiac fibrosis, left ventricular hypertrophy prevention, and improved survival rates following myocardial infarction. Research shows 31.8% vs 56.9% mortality reduction and decreased cardiac rupture rates from 51% to 27% in experimental models. Studies reveal enhanced endothelial cell migration, improved angiogenesis, and reduced inflammatory cell infiltration, positioning it as valuable tool for investigating heart failure prevention and cardiac repair mechanisms.
Pulmonary Fibrosis Research
Comprehensive studies demonstrate both preventive and therapeutic effects against bleomycin-induced pulmonary fibrosis with reduced mortality, inflammation, and collagen deposition. Research shows inhibition of TGF-β signaling, decreased α-SMA expression, and prevention of epithelial-mesenchymal transition. Applications include investigating idiopathic pulmonary fibrosis mechanisms, lung injury repair pathways, and novel anti-fibrotic therapeutic approaches.
Renal Protection Studies
Research reveals significant nephroprotective effects including reduced albuminuria, preserved glomerular filtration rate, and decreased chronic kidney disease progression. Studies demonstrate prevention of tubulointerstitial fibrosis, reduced inflammatory cell infiltration, and improved renal function in 5/6 nephrectomy models. Applications encompass diabetic nephropathy research, hypertensive kidney disease studies, and acute kidney injury prevention investigations.
Stroke & Neuroprotection Research
Clinical studies demonstrate substantial reduction in stroke-induced brain infarct volume and neurological deficits when combined with tissue plasminogen activator. Research shows enhanced blood-brain barrier function, reduced fibrin extravasation, and decreased microglial activation. Studies reveal increased hippocampal neurogenesis and improved cognitive function, making it valuable for investigating cerebral ischemia recovery and neurodegenerative disease prevention.
Cancer Treatment Support
Research demonstrates significant protection against chemotherapy and radiation-induced organ toxicity including cardiac, renal, and bone marrow protection. Studies show reduced mortality from doxorubicin cardiotoxicity and enhanced bone marrow recovery following radiation therapy. Applications include investigating treatment-related side effect prevention and improving cancer therapy tolerance through organ protection strategies.
Mechanism of Action
Macrophage Inhibition: Prevention of bone marrow stem cell differentiation into inflammatory macrophages
TGF-β Suppression: Direct inhibition of transforming growth factor-β expression and signaling pathways
Angiogenesis Promotion: Enhanced endothelial cell migration and blood vessel formation
Anti-Proliferative Effects: Cell cycle arrest in G0/G1 phase preventing excessive tissue proliferation
MEK-ERK Modulation: Regulation of mitogen-activated protein kinase signaling pathways
ACE Pathway Integration: Synergistic effects with angiotensin-converting enzyme inhibition
Research Advantages
Oral Bioavailability: Convenient capsule form providing consistent dosing and improved compliance
Multi-System Protection: Simultaneous cardiovascular, pulmonary, renal, and neurological applications
Clinical Foundation: Extensive validation across multiple disease models with proven safety profiles
Anti-Fibrotic Specificity: Targeted prevention and reversal of pathological scarring processes
Synergistic Potential: Enhanced efficacy when combined with ACE inhibitors and standard therapies
Natural Origin: Endogenous tetrapeptide with established physiological role and safety profile
Ready-to-Use Format: No reconstitution required enabling immediate research application
Quality Specifications
Every Ac-SDKP capsule batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Tetrapeptide sequence verification (Ac-Ser-Asp-Lys-Pro)
Molecular weight confirmation at 487.5 g/mol
CAS number validation (120081-14-3)
PubChem CID verification (65938)
Endotoxin testing (<0.1 EU/mg)
Certificate of Analysis provided with shipment
Storage & Administration
Store capsules at room temperature in sealed bottle. Protect from moisture and excessive heat. Capsules maintain stability for 24 months when stored properly. For research applications, capsules may be opened and contents dissolved in appropriate research media. Each capsule contains precisely measured 500mcg dose enabling consistent research protocols.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.