Molecular Formula: C₁₆H₂₂N₆O₄
Molecular Weight: 362.39 g/mol
Sequence: Pyr-His-Pro
Purity: >99%
Vial Size: 20mg
Storage: -20°C, protect from light
Product Overview
TRH represents revolutionary hypothalamic neuropeptide technology designed for comprehensive neurological, psychiatric, and endocrine research applications. This synthetic tripeptide, originally isolated from hypothalamic tissue, demonstrates exceptional ability to modulate thyroid axis function while providing potent neuroprotective, antidepressant, and cognitive enhancement effects. Unlike traditional antidepressants, TRH rapidly crosses the blood-brain barrier and directly activates multiple neurotransmitter systems without affecting peripheral thyroid function at therapeutic doses.
Revolutionary Neuroendocrine Mechanism
TRH functions as a pleiotropic neuropeptide hormone, primarily targeting thyrotropin-releasing hormone receptors (TRH-R1 and TRH-R2) coupled to Gq/G11 proteins throughout the central nervous system. The peptide activates phosphoinositide-specific phospholipase C, generating inositol triphosphate and diacylglycerol second messengers that mobilize intracellular calcium and activate protein kinase C pathways. This mechanism stimulates TSH release from anterior pituitary while simultaneously providing direct CNS effects independent of thyroid axis activation.
Primary Research Applications
Depression & Suicide Prevention Studies
Clinical validation demonstrates rapid antidepressant effects with 62.5% patient response rates showing 50% or greater symptom reduction. Studies reveal significant reduction in suicidal ideation within hours of administration, particularly effective in women without anxiety symptoms. Research applications include investigating novel rapid-acting antidepressant mechanisms, suicide prevention strategies, and mood regulation pathways independent of traditional serotonergic systems.
Motor Memory & Cerebellar Research
Research demonstrates enhanced motor learning capabilities through direct cerebellar modulation. Studies show improved performance on rotarod tests with nearly double learning retention rates in TRH-treated subjects. Applications include investigating procedural memory formation, cerebellar degenerative diseases, ataxia treatment mechanisms, and motor skill acquisition enhancement in neurological rehabilitation settings.
Opioid Overdose Reversal Studies
Breakthrough research demonstrates dose-dependent respiratory stimulation without affecting analgesic properties. Studies show 100% survival rates in overdose models through brainstem respiratory drive activation. Unlike naloxone, TRH maintains pain control while reversing respiratory depression, positioning it as revolutionary tool for opioid crisis research and emergency medicine applications.
Ischemia & Neuroprotection Research
Studies demonstrate significant neuroprotective effects through enhanced hippocampal cell survival, reduced apoptosis, and improved Morris water maze performance following ischemic injury. Research shows upregulated TRH expression correlates with neuronal survival rates. Applications include stroke recovery mechanisms, traumatic brain injury studies, and cerebral blood flow optimization research.
Alzheimer's & Cognitive Enhancement
Research demonstrates inhibition of tau protein phosphorylation through MAPK activation and GSK3β inhibition, preventing neurofibrillary tangle formation. Studies show reduced glutamate-induced calcium increases and enhanced cholinergic pathway activation. Applications encompass dementia prevention research, cognitive enhancement studies, and amyloid plaque formation investigation.
Mechanism of Action
Thyroid Axis Regulation: TSH stimulation with controlled T3/T4 release for metabolic research applications
Neuroprotection: Enhanced neuronal survival through multiple anti-apoptotic and trophic pathways
Neurotransmitter Modulation: Direct effects on norepinephrine, serotonin, and dopamine systems
Respiratory Stimulation: Brainstem activation increasing breathing rate without peripheral effects
Motor Learning Enhancement: Cerebellar pathway optimization for procedural memory formation
Anti-Aging Effects: Oxidative stress reduction and cellular regeneration promotion
Research Advantages
Rapid Onset: Measurable effects within minutes to hours of administration
Blood-Brain Barrier Penetration: Direct CNS access for neurological research applications
Multi-Target Activity: Simultaneous effects on mood, cognition, motor function, and neuroprotection
Clinical Foundation: Extensive human studies validating safety and efficacy profiles
Minimal Side Effects: Well-tolerated with reversible autonomic effects
Diagnostic Applications: FDA-approved for thyroid axis function testing
Emergency Medicine Potential: Life-saving applications in overdose and trauma settings
Quality Specifications
Every TRH batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Tripeptide sequence verification (Pyr-His-Pro)
Molecular weight confirmation at 362.39 g/mol
CAS number validation (24305-27-9)
Endotoxin testing (<0.1 EU/mg)
Bioactivity assays using TRH receptor binding protocols
Certificate of Analysis provided with shipment
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with sterile bacteriostatic water immediately before use. Once reconstituted, use within 24 hours or store at -80°C for short-term applications. Avoid repeated freeze-thaw cycles to maintain receptor binding affinity and neuropeptide potency.
Research Protocol Applications
Depression and suicide prevention mechanism studies
Motor learning and cerebellar function research
Opioid overdose reversal and respiratory stimulation investigations
Ischemia/reperfusion injury and neuroprotection studies
Alzheimer's disease and cognitive enhancement research
Thyroid axis function and diagnostic testing applications
Emergency medicine and trauma recovery studies
Anti-aging and cellular regeneration investigations
Clinical Translation Potential
TRH benefits from decades of clinical validation with FDA approval for diagnostic applications and extensive research in psychiatric, neurological, and emergency medicine settings. The peptide's proven mechanisms in rapid antidepressant action, neuroprotection, and life-saving emergency applications provide unparalleled foundation for investigating novel therapeutic approaches across multiple medical disciplines.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.