Molecular Formula: C₁₅H₂₆N₄O₈
Molecular Weight: 390.39 g/mol
Sequence: Lys-Glu-Asp (KED)
Purity: >99%
Vial Size: 20mg
Storage: -20°C, protect from light
Product Overview
Vesugen represents revolutionary vascular bioregulatory peptide technology designed for comprehensive cardiovascular, neurological, and anti-aging research applications. This Khavinson-developed tripeptide demonstrates exceptional ability to protect the vascular system from age-related decline by limiting atherosclerosis development, decreasing endothelial cell dysfunction, and promoting cellular regeneration through sirtuin 1 pathway activation. Unlike traditional cardiovascular interventions, Vesugen works epigenetically by directly interacting with DNA to regulate gene expression and restore youthful vascular function.
Revolutionary Vasoprotective Mechanism
Vesugen functions as a specialized vascular bioregulator through direct interaction with DNA minor grooves, forming hydrogen bonds with specific base pairs to regulate Ki-67 proliferation marker expression in endothelial cells. The peptide binds to the CATC sequence in the MKI67 gene promoter region, stimulating proliferative protein expression that naturally decreases with aging. This epigenetic regulation enhances endothelial cell renewal capacity, normalizes endothelin-1 expression, and increases sirtuin 1 levels to provide comprehensive vascular protection and regeneration.
Primary Research Applications
Cardiovascular Protection Studies
Clinical validation demonstrates significant improvements in atherosclerosis and cardiovascular disorders, particularly in elderly populations. Research shows normalized endothelin-1 expression, enhanced connexin communication between cells, and improved vascular stenosis prevention. Studies reveal decreased angina frequency, reduced cardiac arrhythmias, normalized sleep patterns, and long-term remission between hypertensive crises when combined with standard therapy.
Anti-Aging & Longevity Research
Comprehensive studies demonstrate Vesugen's geroprotective properties through sirtuin 1 activation, mimicking beneficial effects of calorie restriction without dietary limitations. Research shows improved biological age markers, enhanced anabolic cellular effects, and significant slowing of aging processes. Applications include investigating cellular senescence mechanisms, DNA repair pathways, and life extension strategies through metabolic optimization.
Neurological Enhancement Studies
Research demonstrates improved memory function in elderly individuals with CNS disorders, restored synaptic plasticity, and enhanced neuronal survival rates. Studies show regulation of apoptosis genes (p16, p21), neuronal differentiation markers (NES, GAP43), and Alzheimer's disease-related genes (SUMO, APOE, IGF1). Applications encompass neuroprotection research, hypoxia resistance studies, and neurodegenerative disease prevention.
Diabetes & Metabolic Research
Studies reveal enhanced insulin sensitivity through sirtuin 1 activation, improved glucose metabolism, and metabolic syndrome prevention. Research demonstrates PGC1-alpha and ERR-alpha complex regulation, leading to optimized metabolic pathways and improved insulin resistance. Applications include investigating diabetic complications, metabolic dysfunction, and therapeutic approaches for metabolic disorders.
Addiction & Reward Pathway Studies
Research demonstrates sirtuin 1 regulation of D1-type dopaminergic spiny neurons in the central nervous system, affecting motivation, reward, and habit formation. Studies suggest potential applications in addiction treatment, schizophrenia research, and Parkinson's disease through dopaminergic system modulation.
Mechanism of Action
Epigenetic Regulation: Direct DNA binding in minor grooves to regulate Ki-67 and other proliferation-associated genes
Sirtuin 1 Activation: Enhanced longevity protein expression promoting DNA repair and cellular protection
Endothelial Restoration: Normalized endothelin-1 levels and improved connexin-mediated cell communication
Anti-Atherosclerotic Effects: Prevention of lipid peroxidation and vascular plaque formation
Neuroprotection: Enhanced neuron survival, synaptic plasticity, and resistance to hypoxic conditions
Metabolic Optimization: Improved insulin sensitivity and metabolic pathway regulation
Research Advantages
Clinical Foundation: Extensive validation in elderly patients with proven cardiovascular benefits
Multi-System Effects: Simultaneous vascular, neurological, and metabolic applications
Oral Bioavailability: Demonstrated effectiveness through oral administration routes
Epigenetic Action: Direct DNA interaction providing targeted gene expression regulation
Calorie Restriction Mimetic: Achieves longevity benefits without dietary restrictions
Minimal Side Effects: Well-tolerated bioregulatory approach with established safety profile
Synergistic Potential: Enhanced efficacy when combined with other bioregulatory peptides
Quality Specifications
Every Vesugen batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Tripeptide sequence verification (Lys-Glu-Asp)
Molecular weight confirmation at 390.39 g/mol
PubChem CID validation (87571363)
Endotoxin testing (<0.1 EU/mg)
DNA binding affinity assessment
Certificate of Analysis provided with shipment
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with sterile bacteriostatic water immediately before use. Once reconstituted, use within 24 hours or store at -80°C for short-term applications. Avoid repeated freeze-thaw cycles to maintain DNA binding affinity and vasoprotective potency.
Research Protocol Applications
Cardiovascular protection and atherosclerosis prevention studies
Anti-aging mechanism investigations and longevity research
Neurological enhancement and neuroprotection studies
Diabetes complications and metabolic syndrome research
Addiction pathway and dopaminergic system investigations
Epigenetic regulation and gene expression studies
Vascular regeneration and endothelial function research
Sirtuin pathway and DNA repair mechanism studies
Clinical Translation Potential
Vesugen benefits from decades of investigation by Professor Vladimir Khavinson with extensive clinical validation in cardiovascular and neurological applications. The peptide's proven mechanisms in vascular protection, anti-aging effects, and neuroprotection provide robust foundation for investigating novel therapeutic applications in cardiovascular disease, neurodegenerative disorders, and age-related conditions.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.