Molecular Formula: C₁₁H₂₁N₃O₅
Molecular Weight: 275.30 g/mol
Sequence: Lys-Glu (KE)
Purity: >99%
Vial Size: 20mg
Storage: -20°C, protect from light
Product Overview
Vilon represents revolutionary bioregulatory peptide technology designed for comprehensive anti-aging, cancer prevention, and immune enhancement research applications. This Khavinson-developed dipeptide holds the distinction of being the shortest peptide known to possess biological activity, demonstrating exceptional ability to reactivate silenced genes through chromatin deheterochromatinization and restore youthful cellular function. Unlike broad immunosuppressants, Vilon specifically targets age-related gene silencing while enhancing immune surveillance and promoting cellular regeneration.
Revolutionary Chromatin Mechanism
Vilon functions as a specialized epigenetic regulator through direct interaction with heterochromatin structures, inducing progressive deheterochromatinization of facultative heterochromatin that accumulates with cellular aging. The peptide selectively reactivates ribosomal genes by decondensing nucleolus organizer regions while releasing genes repressed due to euchromatic condensation. This mechanism restores transcriptional activity to genes silenced through aging processes without affecting constitutive pericentromeric heterochromatin, preserving essential chromosomal stability.
Primary Research Applications
Anti-Aging & Longevity Studies
Comprehensive research demonstrates Vilon's ability to extend lifespan in animal models through enhanced physical activity, increased endurance, and reduced cancer incidence. Studies show greater anti-aging effects when administered early in life, suggesting protective mechanisms against cellular senescence. Research reveals improved gastrointestinal enzyme activity, enhanced barrier function preventing leaky gut, and optimized glucose and glycine absorption in aged subjects.
Cancer Prevention Research
Clinical validation demonstrates 50% reduction in spontaneous tumor incidence with inhibition of tumor growth progression in established malignancies. Research shows Vilon suppresses HER-2/neu oncogene expression by 50% in transgenic models while stimulating apoptosis in both young and aged specimens. Applications include investigating cancer surveillance mechanisms, tumor suppression pathways, and prevention strategies through immune enhancement.
Immune System Enhancement
Studies demonstrate Vilon's capacity to activate interleukin-2 signaling in splenocytes, stimulate CD4 and CD5 T-cell differentiation, and enhance cytotoxic CD8 T-cell function. Research shows increased proliferation of mature T-helper cells while maintaining protection against autoimmune reactions. Applications encompass immunodeficiency research, infection resistance studies, and immune aging reversal investigations through chromatin reactivation.
Cardiovascular & Renal Protection
Research reveals significant gene expression changes in cardiac tissue (36 genes individually, 144 genes combined with Epithalon) indicating cardiovascular regulatory effects. Studies demonstrate decreased transforming growth factor-beta1 levels, reduced microvascular permeability, and improved hemostasis during renal failure. Applications include investigating vascular health, coagulation optimization, and organ protection mechanisms.
Neurological Enhancement Research
Studies demonstrate telomere length normalization in PHA-stimulated lymphocytes across age groups and regulation of key longevity genes including IGF1, FOXO1, TERT, TNKS2, and NF-κB. Research shows potential neuroprotective effects through enhanced cellular regeneration and reduced inflammatory processes affecting neural tissue health.
Mechanism of Action
Chromatin Deheterochromatinization: Progressive reactivation of facultative heterochromatin silenced during cellular aging
Gene Expression Regulation: Selective reactivation of ribosomal and cellular function genes without affecting structural chromatin
Immune Modulation: Enhanced T-cell differentiation, cytokine production, and immune surveillance capabilities
Telomere Maintenance: Normalization of telomere length across age groups through TERT gene regulation
Anti-Oncogenic Effects: Suppression of tumor-promoting genes while enhancing natural cancer surveillance
Metabolic Optimization: Improved nutrient absorption and enzyme function particularly in gastrointestinal tract
Research Advantages
Shortest Active Peptide: Unique distinction as minimal peptide structure with maximal biological activity
Epigenetic Targeting: Direct chromatin interaction providing precise gene reactivation without cellular reprogramming
Early Intervention Benefits: Greater efficacy when administered before extensive cellular aging occurs
Multi-System Effects: Simultaneous anti-aging, immune, cardiovascular, and metabolic applications
Clinical Foundation: Extensive validation by Professor Khavinson with decades of research documentation
Safety Profile: Well-tolerated bioregulatory approach with established long-term administration protocols
Selective Action: Reactivates age-silenced genes without affecting naturally silent genetic regions
Quality Specifications
Every Vilon batch undergoes comprehensive quality control:
HPLC-MS purity analysis confirming >99% purity
Dipeptide sequence verification (Lys-Glu)
Molecular weight confirmation at 275.30 g/mol
CAS number validation (3918-89-6)
Endotoxin testing (<0.1 EU/mg)
Chromatin binding affinity assessment
Certificate of Analysis provided with shipment
Storage & Reconstitution
Store lyophilized powder at -20°C in sealed vials. Protect from light and humidity. Reconstitute with sterile bacteriostatic water immediately before use. Once reconstituted, use within 24 hours or store at -80°C for short-term applications. Avoid repeated freeze-thaw cycles to maintain chromatin-binding affinity and gene reactivation potency.
Research Protocol Applications
Anti-aging and longevity mechanism investigations
Cancer prevention and tumor suppression studies
Immune system enhancement and T-cell differentiation research
Chromatin reactivation and epigenetic regulation studies
Cardiovascular protection and gene expression research
Gastrointestinal function and nutrient absorption studies
Telomere maintenance and cellular aging research
Early intervention and prevention strategy development
Clinical Translation Potential
Vilon benefits from four decades of investigation by Professor Vladimir Khavinson with extensive validation in anti-aging, cancer prevention, and immune enhancement applications. The peptide's proven mechanisms in gene reactivation, immune modulation, and cellular regeneration provide unparalleled foundation for investigating novel therapeutic applications in age-related diseases, cancer prevention, and regenerative medicine.
Research Use Only: Not for human or veterinary therapeutic applications. Handle according to laboratory safety protocols and institutional research guidelines.